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Prandase is a generic name for the medication that also goes by the brand name Glucobay. Prandase is used in conjunction with diet to lower blood sugar in people who have type 2 diabetes mellitus and cannot control it with diet alone. Prandase is given in pill form and can be used along with a sulfonylurea or with insulin when diet plus Prandase is still not enough to keep blood sugar down. It is in a class of medications called alpha-glucosidase inhibitors, which means that it keeps the body from processing carbohydrates efficiently. This results in a smaller and more gradual release of blood sugar throughout the day. Prandase is not intended to work by itself. Prandase is not to be used as a substitute for diet and exercise, but in addition to them. The first line of defense for the treatment of type 2 diabetes mellitus is always diet and lifestyle. In some severe cases, diet and lifestyle changes alone may not be enough to keep blood sugar controlled, so Prandase is prescribed as a secondary, assisting measure.

The most common side effects of Prandase are gastrointestinal symptoms such as abdominal pain, diarrhea, and flatulence. Most studies have shown that these symptoms tend to get better with time. These side effects will be much worse for those who are not following a prescribed diet and are taking Prandase. Other serious but rare effects include skin rash or hives, fatigue, weight loss or appetite loss, dark or brownish urine, or loss of appetite. You should also let your doctor know if you have hiatal hernia, kidney or liver disease, stomach or bowel disease, any kind of bowel obstruction, or allergies of any sort.

Some drugs should not be taken at the same time as Prandase. These drugs include thiazides or other diuretics, oral contraceptives, thyroid treatments, estrogens, phenytoin, sympathomimetics, nicotinic acid, calcium channel blockers, and isoniazid. If you do take these drugs at the same time as Prandase, you should be monitored carefully by your doctor to make sure your blood sugar doesn’t become uncontrolled. If you are receiving sulfonylureas or insulin at the same time as Prandase, you may find that your blood sugar is too low, which could, in extreme cases, lead to hypoglycemic shock. It has also been shown that intestinal absorbents such as charcoal may reduce the effect of Prandase. If you’re taking digoxin along with Prandase, your doctor may wish to reduce your dose of digoxin.

Prandase is in Pregnancy Category B, which means that it is not known whether it is safe to take during pregnancy or not. Animal tests suggest that it is largely safe, but animal tests do not always predict the outcome accurately for humans, so Prandase should be avoided by pregnant women. It is not yet known whether Prandase is effective or safe in breast milk, but studies indicate that it does pass into the mother’s milk. Therefore, Prandase should not be administered to nursing women. It has also not been evaluated for use in children.

Prandase has the following structural formula:

Chemical structure of prandase

• Molecular formula of prandase is C25H45N3O16
• Chemical IUPAC Name is (2R,3R,4S,5R,6R)-5-[(2R,3R,4S,5R,6R)-5-[(2R,3R,4S,5R,6R)-3, 4-dihydroxy-6-methyl-5-[[(1S,4S,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)- 1-cyclohex-2-enyl]amino]oxan-2-yl]oxy-3,4-dihydroxy- 6-(hydroxymethyl)oxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,3,4-triol
• Molecular weight is 643.635 g/mol
Prandase available : 25mg tablets, 50mg tablets, 100mg tablets

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