Original: http://www.medicalook.com/reviews/Amiloridum.html


Your body usually balances the chemicals it produces; however, sometimes it needs help from outside sources. Amiloridum is used to counteract hypertension and congestive heart failure. Usually these diseases come from an overload of sodium in the body. Amiloridum, more commonly known to doctors as a Potassium-sparing diuretic, is used to keep potassium in the body but release sodium. More specifically, it keeps sodium and water from being absorbed in the kidneys. Unlike other diuretics Amiloridum keeps the potassium from seeping out as well. This helps normalize the functions of the heart and the kidneys.

Sometimes, because of the potassium the body handles, patients using this medication experience hyperkalemia, which is simply a high blood potassium level. Using ACE inhibitors and spironolactone usually triggers this condition. This is easily managed by adjusting the dosage of Amiloridum. To help regulate the body fluids, this medication is usually taken with thiazide and loop diuretics. Doctors prescribe Amiloridum with another medication to combat the hyperkalemia.

Using medications that increase the levels of potassium in the body is very delicate. If you are taking any medication for high blood pressure, potassium supplements, or diabetes, you should inform your doctor. Lithium is especially dangerous to be taking while on Amiloridum. Also medications like captopril, digoxin, and lisinopril can be dangerous when taking Amiloridum. Medications like spironolactone can increase your potassium to a dangerous level when taken with Amiloridum, so inform your doctor about these and all other medications that you are taking. If patients have had liver, kidney or heart disease then they should inform their doctors immediately. Since Amiloridum increases the body’s potassium, the organs recovering from these diseases might be susceptible to the change. Having a renal disease is particularly hard if you plan on taking Amiloridum since this makes the body more susceptible to hyperkalemia.

Amiloridum has some common, negligible side effects such as headache, fatigue, upset stomach, gas, nausea, muscle cramps, and frequent urination. Some rare side effects include impotence, vertigo, heartburn, back and chest pain. A difficult but common side effect is drowsiness, so patients on this medication should be careful not to drive or operate heavy machinery. Patients that experience skin rashes, yellow eyes or skin, difficulty breathing or an irregular heartbeat should contact your doctor immediately. Side effects of a serious nature should always be reported to the treating physician.

Amiloridum is usually sold under the name Midamor in 5mg and 10 mg tablets. These tablets are usually yellow and diamond shaped. Doses usually start at 5mg daily and then are slowly increased if the patient’s doctor sees fit, but higher doses usually put patients at risk for high blood potassium levels. The effects of the medication last the entire day, but usually it is most effective 6-8 hours after taking it. Since the aim of Amiloridum is to regulate sodium levels, patients are encouraged to follow a low-sodium diet and exercise regularly. Also, it is best to stay away from potassium rich foods like bananas, prunes and raisins while on Amiloridum.

Amiloridum has the following structural formula:

Chemical structure of amiloridum

• Molecular formula of amiloridum is C6H8ClN7O
• Chemical IUPAC Name is 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
• Molecular weight is 229.6270 g/mol
Amiloridum available : 5mg tablets

©2007-2017 Medicalook.com All rights reserved