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Besacholine


Besacholine is a parasympathomimetic choline ester, a medication that has a stimulating effect on muscarinic receptors that are responsible for the contraction of the smooth muscle tone. It is usually prescribed to patients who have recently had abdominal surgery, given birth, or who suffer from urinary retention to help them empty their bladder.

Besacholine is also recommended for oral or subcutaneous (under the skin) administration to ease urinary retention caused by general anesthesia in surgery, diabetic neuropathy of the bladder (a diabetes complication that causes nerve damage), in the management of gastrointestinal atony (lack of gastric muscular tone), and bladder overdistention (the bladder retains an abnormal amount of residual urine).

In general, Besacholine is used to treat voiding problems caused by a malfunction of the bladder's nerves or weak bladder muscles, as long as there has been no prior diagnosis of urinary blockage. It is also indicated for digestive problems like gastroesophageal reflux (heartburn).

Besacholine stimulates the muscarinic receptors in the bladder and gastrointestinal tract, causing them to contract and expel urine, as well as improve gastrointestinal motility, increase gastric tone and bring back peristalsis, the regular contraction of smooth muscles which moves the contents of the digestive tract onward.

Before taking Besacholine, patients should tell their doctor if they suffer from stomach ulcers, uncontrolled hyperthyroidism (overactive thyroid), asthma, recent bladder or intestinal surgery, intestinal blockage or bowel disease, slow heart rate or low blood pressure, coronary artery disease, difficult voiding, Parkinson's disease, or any kind of seizure disorder like epilepsy. Patients with these conditions are advised not to take Besacholine, or if necessary, have their doctor prescribe a lower dose and monitor them constantly during the course of treatment.

Patients should also inform their doctor if they have any allergic reactions to Besacholine, tartrazine dye, food preservatives or any other medicines. Female patients should also let their doctor know if they are pregnant or plan to become pregnant. Besacholine has been categorized by the FDA as pregnancy category C, and it is yet unknown if the medication has the potential to harm an unborn baby. Breastfeeding mothers should likewise talk to their doctors before taking Besacholine.

Other medications may also react adversely with Besacholine. Patients taking quinidine, donezipil, tacrine, procainamide, cholinesterase inhibitors, ganglionic blocking compounds, and medications used for colds or nasal congestion may experience negative reactions when taking them with Besacholine. In all other cases, patients should give their doctor a list of all the prescription and non-prescription medications they are taking, including vitamin, mineral and herbal supplements.

Besacholine can cause drowsiness and patients on medication should refrain from driving or operating any kind of machinery. Alcoholic beverages can also contribute to the dizziness caused by the medication. Besacholine may also affect some blood tests, and patients should inform their doctor that they are on medication before undergoing any blood tests.

Besacholine may result in side effects including stomach upsets, increased salivation, nausea, vomiting, sweating or flushing. If the patient experiences shortness of breath, a slow heart rate, hypotension (low blood pressure), bronchial spasms or fainting, they should call their doctor immediately. If there are extreme allergic reactions like swelling of the lips, tongue or face, hives, closing of the throat, wheezing and tightness in the chest, the patient should seek emergency medical attention immediately.

Bethanecol is a generic medication that is distributed under the brand names Duvoid by Roberts, Myotonachol by Glenwood, and Urecholine by Merck Frosst, which manufactures the medication in 5mg round white tablets, 10mg round pink tablets, 25mg round yellow tablets and 50mg round yellow tablets.

Dosage of the medication depends on the individual condition and the type of illness being treated. Patients are advised to take the medication orally on an empty stomach with plenty of fluids, based on the dose prescribed by their doctor.

Besacholine has the following structural formula:

Chemical structure of besacholine


• Molecular formula of besacholine is C7H17N2O2+
• Chemical IUPAC Name is 2-carbamoyloxypropyl-trimethylazanium
• Molecular weight is 161.2221 g/mol
Besacholine available : 5mg tablets, 10mg tablets, 25mg tablets, 50mg tablets




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