Mechothane is a parasympathomimetic choline ester that has a stimulating effect on muscarinic receptors which are responsible for the contraction of the smooth muscle tone. It is usually administered to patients who have recently had abdominal surgery, given birth, or who suffer from urinary retention to help them empty their bladder. Mechothane is recommended for oral or subcutaneous (under the skin) administration to ease urinary retention caused by general anesthesia in surgery, diabetic neuropathy of the bladder (a diabetes complication that causes nerve damage), in the management of gastrointestinal atony (lack of gastric muscular tone), and bladder overdistention (the bladder retains an abnormal amount of residual urine).
Mechothane is used to treat urination problems caused by a malfunction of the bladder's nerves or weak bladder muscles, so long as there has been no prior diagnosis of urinary blockage. It is also given to patients for digestive problems like gastroesophageal reflux (heartburn).
Mechothane stimulates the muscarinic receptors in the bladder and gastrointestinal tract, which causes them to contract and expel urine, as well as improve gastrointestinal motility, increase gastric tone and bring back peristalsis, the regular contraction of smooth muscles, which moves the contents of the digestive tract onward.
Prior to taking Mechothane, patients should disclose their complete medical history to their doctor, including if they suffer from stomach ulcers, uncontrolled hyperthyroidism (overactive thyroid), asthma, recent bladder or intestinal surgery, intestinal blockage or bowel disease, slow heart rate or low blood pressure, coronary artery disease, difficult urination, Parkinson's disease, or any kind of seizure disorder like epilepsy. Patients with these conditions are advised not to take Mechothane, or have their doctor prescribe a lower dose and monitor them constantly during the course of treatment.
Patients should inform their doctor if they have any allergic reactions to Mechothane, tartrazine dye, food preservatives or any other medicines. Female patients should let their doctor know if they are pregnant or plan to become pregnant. Mechothane has been categorized by the FDA as pregnancy category C, and it is unknown if the medication poses harm to an unborn baby. Breastfeeding mothers should talk to their doctors before taking Mechothane.
Other medicaments may react adversely with Mechothane. Patients taking quinidine, donezipil, tacrine, procainamide, cholinesterase inhibitors, ganglionic blocking compounds, and medicaments used for colds or nasal congestion may experience negative reactions when taking these medicaments with Mechothane. In all other cases, patients should give their doctor a list of all prescription and non-prescription medicaments they are taking, including vitamins, minerals and herbal supplements.
Mechothane can cause drowsiness and patients taking this medication should refrain from driving or operating any kind of machinery. Alcoholic beverages can contribute to the dizziness caused by the medication, so patients taking this medication should refrain from consuming alcoholic beverages. Mechothane may affect some blood tests, so patients should inform their doctor that they are taking this medication before undergoing any blood tests.
Mechothane's side effects include upset stomach, increased salivation, wamble, vomiting, sweating or flushing. If the patient experiences shortness of breath, a slow heart rate, hypotension (low blood pressure), bronchial spasms or fainting, call their doctor immediately. If there are extreme allergic reactions like swelling of the lips, tongue or face, hives, closing of the throat, wheezing and tightness in the chest, seek emergency medical attention immediately.
Bethanecol is a generic medication distributed under the brand names Duvoid by Roberts, Myotonachol by Glenwood, and Urecholine by Merck Frosst, which manufactures the medication in 5mg round white tablets, 10mg round pink tablets, 25mg round yellow tablets and 50mg round yellow tablets.
Proper dosage of the medication depends on the patient, their condition and the type of illness being treated. Patients are advised to take the medication orally on an empty stomach with plenty of fluids, based on the dosage prescribed by their doctor.
Mechothane has the following structural formula:
• Molecular formula of mechothane is C7H17N2O2+
• Chemical IUPAC Name is 2-carbamoyloxypropyl-trimethylazanium
• Molecular weight is 161.2221 g/mol
• Mechothane available : 5mg tablets, 10mg tablets, 25mg tablets, 50mg tablets
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