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Buprenophine


Buprenophine, a sublingual medication used to treat patients addicted to or dependent on narcotics, is sold under the brand names Subutex and Temgesic. This medication reduces the patients withdrawal symptoms by retarding the patients perceived urgency of seeking opioid substances. Being a narcotic itself, it is widely used by doctors, medical professionals and medical practitioners as part of a therapeurinary tract infectionc regimen of narcotic dependents.

The main effect during administration is a long lasting analgesic effect, which is a benefit for most patients because of a longer consistent therapy management. Other benefits of this medication are its low medication interactions, low profile administration through the sublingual or transdermal routes, least amount of renal accumulation, and its lack of any type of immune system suppressant. This lessens the side effects experienced by most patients.

Those with intense to moderately rated chronic pain should be treated with Buprenophine, especially those who are set to have an operation. This medication is a common peri-operative medication urinary tract infectionlized among cancer patients.

Those suffering from depression or psychosis may be treated successfully with Buprenophine. However, doctors in the psychiatric division have not included psychological distress in the official list of tested and approved indications for this medication. The conflict of successful therapeurinary tract infectionc claims of the medication over such ailments versus the actual approval in the medical field elicits debates and lands the medication in a gray area in this regard.

The most common dosage for this medication is available in both 2 and 8 milligram variants, wherein adults whose age is 13 years and above may be administered 1 milliliter of the medication containing .3mg of Buprenophine. It is usually administered through intramuscular route and is given in a slow push, lasting up to 2 minutes. Intervals as prescribed by the physician may go as often as every 6 hours.

For children, the usual dosage would be 2 to 6 micrograms per kilo of body weight given every 4 hours. Some doctors may administer the medication at 6-hour intervals for better body compliance.

In a clinical test of about 1,133 patients sedated with this medication, about two thirds of the specimen population showed side effects overall, with different effects. Even with the high level of side effects, the intensity of the said effects was minimal or negligible. As an added note, those patients who were successfully sedated were able to be roused back to an alert state quite easily.

Most common side effects occurring with the test sample population was Nausea and Vertigo, which occurred in 5 to 10% of the whole population. Other symptoms include perspiration or diaphoresis, hypotension, vomiting, headache, and hypoventilation.

There are some adverse side effects that occur in rare occasions such as loss of appetite, agitation, diarrhea, hives, and neuromuscular impairment as evidenced by occasional convulsions and muscle twitching.

Medication interaction is documented with CYP3A4 isozymes in the body, which may lower the clearance of the medication in the bloodstream.

As for CYP3A4 inducers such as rifampin, phenytoin, and phenytoin may actually help clearance of the body.

Pregnant women should take special precaurinary tract infectionon with this medication as it may affect normal fetal growth.

Buprenophine has the following structural formula:

Chemical structure of buprenophine


• Molecular formula of buprenophine is C29H41NO4




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