Ambochlorin is a powerful chemotherapy medication that is commonly used in treating chronic lymphocytic leukemia. Ambochlorin was formerly used against some types of non-Hodgkin lymphoma, ovarian carcinoma, and others. It was also used as an immunosuppressive medication for a number of inflammatory and autoimmune conditions, including nephrotic syndrome. Nowadays, it is mainly used in cases of chronic lymphocytic leukemia.
Ambochlorin is sold by GlaxoSmithKline under the brand name Leukeran. It is prescribed for people suffering from Hodgkin's disease, chronic lymphocytic leukemia, and Waldenstrom's macroglobulinaemia, among others.
There is a varying dosage for each type of condition. For example, for Waldenstrom's macroglobulinaemia, the initial dose is 6-12 mg per day until leucopenia develops. Afterwards, the maintenance dose is 2-8 mg per day. Since Ambochlorin comes in 2 mg per brown tablet, the maintenance can range from one to four tablets per day.
Ambochlorin should be taken with proper supervision of a doctor. This is also best taken on an empty stomach with lots of water. Make sure that you don't chew or crush the tablet.
In case you forget your dosage, do not take a double dosage on your next schedule. Inform your doctor and continue with your usual dosage. Another case is if you vomit right after taking Ambochlorin, seek your doctor's advice whether to take another or not.
If you are taking this medication, bruising or bleeding is a normal occurrence. Since the blood would lose platelet production, the ability of the blood to clot is affected. It is necessary to contact your doctor if you experience bleeding gums or blood spots.
Another major side effect is anaemia. When you have anaemia, you feel tired more often. You also feel as if you are always breathless. At the same time, wamble and emesis may also be experienced. These can be controlled or lessened by some anti-emetic medications.
Patients will experience a lowered resistance level. Because of this, you may be prone to illnesses like colds. While taking Ambochlorin, you may lose your appetite; however, there are still some tips that your doctors and dieticians can give you so you can maintain a healthy weight.
In very rare cases, some people taking Ambochlorin develop mouth sores, ulcers, diarrhea, seizures, or fits, while some also report changes in food taste. There may be effects on the liver, which are reversible after treatment.
There are some fertility issues when taking Ambochlorin. That is why it is advised to discuss contraception before taking this medication.
Patients currently taking azidamfenicol are cautioned against taking Ambochlorin. A combination of these medications would result to additive toxicity. This can be fatal and causes permanent damage.
There might be additional medications prescribed alongside Ambochlorin to prevent or lessen the side effects. These may include anti-emetic medications and anti-diarrhea medications. In such cases, keep in mind that you should inform your doctors right away of any reaction of the medications. Doctors may change prescribed medications.
Ambochlorin is mutagenic: it can cause mutations in a person's DNA. Pregnant women should be aware that there are reports that fetus may be affected by it. To be safe, pregnant women are also advised to seek medical assistance on whether to breastfeed or not.
Ambochlorin has the following structural formula:
• Molecular formula of ambochlorin is C14H19Cl2NO2
• Chemical IUPAC Name is 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid
• Molecular weight is 304.212 g/mol
• Ambochlorin available : 2mg tablets
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