Chlocambucil is a powerful chemotherapy medication commonly used in treating chronic lymphocytic leukemia. Chlocambucil was formerly used against some types of non-Hodgkin lymphoma and ovarian carcinoma. It was also used as an immunosuppressive medication for inflammatory and autoimmune conditions, including nephrotic syndrome. Now, it is mainly used in cases of chronic lymphocytic leukemia.
Chlocambucil is distributed by GlaxoSmithKline under the brand name Leukeran. It is for people suffering from Hodgkin's illness, chronic lymphocytic leukemia, and Waldenstrom's macroglobulinaemia, among others.
There is a varying dose for each condition. For example, for Waldenstrom's macroglobulinaemia, the initial dose is 6-12 mg per day until leucopenia develops. After, the maintenance dose is 2-8 mg per day. Since Chlocambucil comes in a 2 mg brown tablet, the maintenance can range from one to four tablets per day.
Chlocambucil should be taken with proper supervision of a doctor. It is also best taken on an empty stomach with lots of water. Make sure that you do not chew or crush the tablet.
If you miss a dose, do not take a double dose at your next scheduled dose. Inform your doctor of the missed dose and continue with your usual dose. If you vomit right after taking Chlocambucil, seek your doctor's advice whether to take another or not.
If you are taking this medication, bruising or bleeding is normal. Since the blood will lose platelet production, the ability of the blood to clot is affected. Contact your doctor if you experience bleeding gums or blood spots.
Another side effect is anemia. When you have anemia, you feel tired often. You also feel as if you are breathless. At the same time, nausea and vomiting may be experienced. These side effects can be controlled or lessened by some anti-emetic medications.
Some patients will experience a lowered resistance level. Because of this, you may be prone to illnesses like colds. While taking Chlocambucil, you may lose your appetite; however, there are still some tips that your doctors and dieticians can give you so you can maintain a healthy weight.
In very rare cases, some people taking Chlocambucil develop mouth sores, ulcers, diarrhoea, seizures, or fits, while some also report changes in food taste. There may be effects on the liver, which are reversible after treatment.
There are some fertility issues when taking Chlocambucil. That is why it is advised to discuss contraception before taking this medication.
Patients currently taking azidamfenicol are cautioned against taking Chlocambucil. A combination of these medications would result to additive toxicity. This can be fatal and causes permanent damage.
There might be additional medications prescribed alongside Chlocambucil to prevent or lessen the side effects. These may include anti-emetic medications and anti-diarrhoea medications. In such cases, keep in mind that you should inform your doctors right away of any reaction of the medications. Doctors may change prescribed medications.
Chlocambucil is mutagenic: it can cause mutations in a person's DNA. Pregnant women should be aware that there are reports that fetus may be affected by it. To be safe, pregnant women are also advised to seek medical assistance on whether to breastfeed or not.
Chlocambucil has the following structural formula:
• Molecular formula of chlocambucil is C14H19Cl2NO2
• Chemical IUPAC Name is 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid
• Molecular weight is 304.212 g/mol
• Chlocambucil available : 2mg tablets
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