Chloroambucil is a powerful chemotherapy medication used to treat chronic lymphocytic leukemia. Chloroambucil has been used against some types of non-Hodgkin lymphoma and ovarian carcinoma and as an immunosuppressive medication for inflammatory and autoimmune conditions, including nephrotic syndrome. Now, it is mainly used to treat cases of chronic lymphocytic leukemia.
Chloroambucil is distributed by GlaxoSmithKline under the brand name Leukeran. It is used to treat patients with Hodgkin's disease, chronic lymphocytic leukemia, and Waldenstrom's macroglobulinaemia.
Dosage varies for each condition. For example, for Waldenstrom's macroglobulinaemia, the initial dose is 6-12 mg per day until leucopenia develops. The maintenance dose is 2-8 mg per day. Since Chloroambucil comes in a 2 mg brown tablet, the maintenance dose can range from one to four pills per day.
Chloroambucil should be taken with proper supervision of a physician. It is also best taken on an empty stomach with lots of water. Make sure that you do not chew or crush the tablet.
If you miss a dose, do not take a double dose at your next scheduled dosage. Inform your physician of the missed dose and continue with your usual dosage. If you vomit after taking Chloroambucil, seek your physician's advice whether to take another dose or not.
When taking this medication, bruising or bleeding is normal. Since the blood loses platelet production, the ability of the blood to clot is affected. Contact your physician if you experience bleeding gums or blood spots.
Another side effect is anemia. When you have anemia, you feel tired often. You also feel as if you are breathless. At the same time, nausea and vomiting may be experienced. These side effects can be controlled or lessened by some anti-emetic medications.
Some patients will experience a lowered resistance level. Due to this, they may be prone to diseases like colds. While taking Chloroambucil, you may lose your appetite. There are some tips that your physician or dietician can give you to maintain a healthy weight.
In rare cases, some patients taking Chloroambucil develop mouth sores, ulcers, diarrhea, seizures, or fits, while some also report changes in food taste. There may be effects on the liver that are reversible after treatment.
There are some fertility issues when taking Chloroambucil. Discuss contraception with your physician before taking this medication.
Patients taking azidamfenicol are cautioned against taking Chloroambucil. The combination of these medications may result in additive toxicity, which can be fatal or cause permanent damage.
There may medications prescribed alongside Chloroambucil to prevent or lessen the possible side effects. These include anti-emetic medications and anti-diarrhea medications. Inform your physician right away of any reaction of the medications. Physicians may change your prescribed medications based on your response to the treatment.
Chloroambucil is mutagenic, meaning that it can cause mutations in a patient's Deoxyribonucleic acid. Pregnant women should be aware that there are reports that fetus may be affected by Chloroambucil. To be safe, pregnant women are advised to talk with their physician regarding this medication before taking it.
Chloroambucil has the following structural formula:
• Molecular formula of chloroambucil is C14H19Cl2NO2
• Chemical IUPAC Name is 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid
• Molecular weight is 304.212 g/mol
• Chloroambucil available : 2mg tablets
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