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Chlorobutin is a powerful chemotherapy medicament used to treat chronic lymphocytic leukemia. Chlorobutin has been used against some types of non-Hodgkin lymphoma and ovarian carcinoma and as an immunosuppressive medicament for inflammatory and autoimmune conditions, including nephrotic syndrome. Now, it is mainly used to treat cases of chronic lymphocytic leukemia.

Chlorobutin is distributed by GlaxoSmithKline under the brand name Leukeran. It is used to treat patients with Hodgkin's disease, chronic lymphocytic leukemia, and Waldenstrom's macroglobulinaemia.

Dosage varies for each condition. For example, for Waldenstrom's macroglobulinaemia, the initial dose is 6-12 mg per day until leucopenia develops. The maintenance dose is 2-8 mg per day. Chlorobutin comes in a 2 mg brown tablet.

Chlorobutin should be taken with proper supervision of a physician. It is also best taken on an empty stomach with lots of water. Make sure that you do not chew or crush the tablet.

If you miss a dose, do not take a double dose at your next scheduled dose. Inform your physician of the missed dose and continue with your usual schedule. If you vomit after taking Chlorobutin, seek your physician's advice whether to take another dose or not.

When taking this medicament, bruising or bleeding is normal. Since the blood loses platelet production, the ability of the blood to clot is affected. Contact your physician if you experience bleeding gums or blood spots.

Another side effect is anaemia, which makes you feel tired and breathless. Nausea and vomiting are also possible side effects. All of these side effects can be controlled or lessened by some anti-emetic medicaments.

Some patients will experience a lowered resistance level and may be prone to illnesses like colds. While taking Chlorobutin, you may lose your appetite. There are tips your physician or dietician can give you to maintain a healthy weight.

In rare cases, patients taking Chlorobutin develop mouth sores, ulcers, diarrhea, seizures, or fits, while some also report changes in food taste. There may be effects on the liver that are reversible after treatment.

There are some fertility issues when taking Chlorobutin. Discuss contraception with your physician before taking this medicament.

Patients taking azidamfenicol are cautioned against taking Chlorobutin. The combination of these medicaments may result in additive toxicity, which can be fatal or cause permanent damage.

There may medicaments prescribed alongside Chlorobutin to prevent or lessen the possible side effects. These include anti-emetic medicaments and anti-diarrhea medicaments. Inform your physician right away of any reaction of the medicaments. Physicians may change your prescribed medicaments based on your response to the treatment.

Chlorobutin is mutagenic, meaning that it can cause mutations in a patient's DNA. Pregnant women should be aware that there are reports that fetus may be affected by Chlorobutin. To be safe, pregnant women are advised to talk with their physician regarding this medicament before taking it.

Chlorobutin has the following structural formula:

Chemical structure of chlorobutin

• Molecular formula of chlorobutin is C14H19Cl2NO2
• Chemical IUPAC Name is 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid
• Molecular weight is 304.212 g/mol
Chlorobutin available : 2mg tablets

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