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Ciflox is very useful in the treatment of an array of bacteria and renders less potential side effects compared to others in its class.

Ciflox is the generic name of the antibiotic that also comes in brand names such as Cipro, Ciprobay and Ciproxin. It is in the group of medicaments called fluoroquinolones which act as bacteriocidals. Generally, bacteria in the human body are eliminated and the growth and spread is stopped through inhibitive actions. Ciflox is useful against a variety of bacterial infections including some urinary tract infections as well as the treatment and prevention of anthrax.

Ciflox is a broad-spectrum antibiotic effective against Gram-negative and Gram-positive bacteria. It directly acts on enzymes to prevent bacterial cell division. Included in the array of bacteria that it fights are enterobacteriaceae, brucella, neisseria, campylobacter, vibrio, mycobacterium intracellulare, legionella sp., pseudomonas aeruginosa, Escherichia coli, streptococcus pneumoniae and Chlamydia. However, it is not as effective in fighting bacteroides, entercoccus faecium, streptococcus pyogenes and ureaplasma urealyticum.

Ciflox can cause several side effects but incidences are mostly safe and manageable. Compared to other fluoroquinolones, severity and frequency is low and usually mild to moderate. Mild to moderate side effects that should be reported to your doctor include nausea, vomiting, stomach pain, indigestion, headache, diarrhea, nervousness, anxiety, irritability, nightmares, insomnia, feelings of distrust, vaginal itching or discharge. Serious side effects should immediately be reported to your doctor and patients should stop taking Ciflox. Symptoms include rashes, hives, joint and myalgia, fainting, irregular heartbeat, hoarseness of voice, tingling sensation, easily fatigued, loss of appetite, fever, hallucination, depression, double vision, seizure, suicidal ideations and loss of sensitivity to touch.

Patients with known hypersensitivity to quinolones and fluoroquinolones should be cautious about taking the medicament. Ciflox may interact negatively with tizanidine, anticoagulants, acetazolamide, anti-diarrheals, methotrexate and anti-inflammatory medicaments. Patients should consult their doctor if they are taking any herbal medicaments or nutritional supplements. Operating machinery and driving are discouraged until the effects of this medicament are fully realized. The medicament also increases skin sensitivity to ultraviolet light and sunlight but sunburns are not normal and should be reported.

Ciflox works to block bacterial DNA proliferation and spread by binding to the DNA gyrase enzyme. This enzyme is a type II topoisomerase and important in separating replicated DNA. The binding action causes double-stranded breaks in the chromosome of the bacteria, which stops cell division. The medicament also directly acts on any existing bacteria by killing them.

In a study, 24 women ages 22 to 32 suffering from urinary tract infections were given 500 mg of Ciflox twice daily in the form of oral tablets. After 1 week, half the women were free from symptoms and by the end of the second week, all women were fully healed. Only 3 participants reported mild side effects while the others did not experience any adverse reactions.

Ciflox is a nonprescription medicament and can be bought at pharmacies and drug stores. Be sure to check the expiration date, manufacturer and location to ensure the product is still good. When buying over the internet, be sure that the source is valid by checking the address and asking for verification.

Ciflox is taken according to the recommended dose. Never double the dose if you miss one. Each dose should be taken with a full glass of water and pills should be swallowed whole, not crushed or chewed. Patients are discouraged from taking the medicament with dairy products. The medicament should be stored at room temperature and kept out of children's reach at all times.

Ciflox has the following structural formula:

Chemical structure of ciflox

• Molecular formula of ciflox is C17H18FN3O3
• Chemical IUPAC Name is 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-quinoline-3-carboxylic acid
• Molecular weight is 331.342 g/mol
Ciflox available : 0.3% solution 10ml bottle, 0.3% solution 2.5ml bottle, 0.3% solution 5ml bottle, 250mg tablets, 500mg tablets, 750mg tablets

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