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Combipres is also known generically as clonidine and chlorthalidone and is commonly used in the treatment of high blood pressure. Combipres is a combination medication. One medication (clonidine) relaxes the blood vessels and allows the heart to pump blood through the body with less resistance as well as slows the rate at which the heart beats. The other medication (chlorthalidone) reduces edema and swelling by increasing the body’s salt and water which is lost in the process of urination. Chlorthalidone is a diuretic.

Combipres may affect patients differently and may cause worsening of some medical conditions. It is recommended that the prescribing physician assess a thorough medical evaluation prior to prescribing Combipres. Patients with a medical history which includes liver disease, a previously known allergy to sulfa based drugs, or the current use of an MAO inhibitor can not take Combipres. Patients with a medical history which includes kidney disease, diabetes, gout, heart attack, stroke, heart disease, pancreatitis, high cholesterol, high level of triglycerides in the blood, or a collagen vascular disease like systemic lupus may or may not be able to tolerate Combipres and may require special monitoring while undergoing drug therapy with Combipres, depending on the condition and the severity of the condition.

According to the American Food and Drug Administration, Combipres has been granted a pregnancy risk category B rating, which means that there is no expectation that Combipres will cause harm or birth defects in a developing fetus. However, Combipres does pass through the mother’s breast milk and could cause harm to a nursing baby. Women who are pregnant should weigh the risks versus the benefits while women who are nursing should avoid taking Combipres. Combipres has not been approved for the therapeutic use in children.

Combipres should be taken exactly as it has been prescribed and patients should never alter their dose without a doctor’s consent. Should a missed dose occur, the dose should simply be taken when it has been remembered unless it is nearing time for the next scheduled dose. If this is the situation, the patient should skip the missed dose and return to a normal dosing schedule with the following dose. Taking double doses or taking too much Combipres within a short period of time can lead to an overdose. An overdose is a medical emergency and if an overdose is suspected the patient should be directed to emergency medical treatment. An overdose might include symptoms such as nausea, vomiting, lightheadedness, seizures, weakness, drowsiness, lethargy, an increase in urination, and a reduced heart rate.

Side effects which may be quite severe may be associated with Combipres for a small percentage of patients. Side effects such as unexplained bruising, unusual bleeding, a lack of urination, chest pain, high blood pressure, low blood pressure, a very slow heart rate or an allergic reaction requires immediate emergency medical attention. Allergic reactions often subject the patient to facial swelling, hives, and difficulty breathing.

Most side effects experienced with Combipres are not as dramatic and may include tingling or numbness in the extremities, fatigue, dizziness, tiredness, insomnia, constipation, diarrhea, nausea, vomiting, abdominal discomfort, muscle weakness, muscle cramps, impotence, sensitivity to light, blurry vision, excessive urination, and an increased thirst and dry mouth. These side effects can often be relieved to a tolerable level by reducing the dosage of Combipres where appropriate, although not all patients will benefit from this. Patients should always report side effects to the prescribing physician to help determine if they can be made more comfortable.

Other medication may react poorly with Combipres and may cause health complications. Patients should always advise their physician of any new medications, including over the counter medications and herbal remedies before taking them. Medications with known interactions with Combipres include medications which are used to lower cholesterol, tricyclic antidepressants, lithium, oral diabetes medications, steroid medications, NSAID pain relievers, and medication used in the treatment of heart conditions or to lower blood pressure.

Combipres has the following structural formula:

Chemical structure of combipres

• Molecular formula of combipres is C9H9Cl2N3
• Chemical IUPAC Name is N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine
• Molecular weight is 230.093 g/mol
Combipres available : 15mg pills

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