Staphylococcus aureus has another medication to worry about - Clindagel. This antibiotic is one of the most effective without patients having to worry about hypersensitivity reactions. Though patients do have to learn more about proper use and observance of adverse effects.
Clindagel is the generic name for the lincosamide antibiotic. It is used to treat infections caused by anaerobic bacteria as well as some protozoal illnesss like malaria. Since it is highly effective against methicillin-resistant Staphylococcus aureus or MRSA infections, Clindagel is also used to treat acne. The medication is available under the brand names Dalacin, Cleocin, Duac and Evoclin.
Clindagel can also be used to treat infections of the respiratory tract, pelvis, abdomen and vagina, peritonitis and septicemia. The medication works well for patients with known hypersensitivity reactions to penicillins. Bone and joint infections from Staphylococcus aureus can also be treated with this medication. The medication comes in capsule form, which should be taken orally. There are also lotions and gels to be applied topically for skin infections.
Various side effects have been associated with the use of the medication. Examples of serious side effects are allergic reactions like face and lip skin edema, breathing difficulty, hives and rash, bloody or watery stool, fever, flu-like symptoms, body aches, nausea, vomiting, loss of appetite, jaundice, scanty or absent urine and headache. Mild and moderate side effects include mild nausea, stomachache, vaginal pruritus or discharge, throat irritation and mild skin pruritus or rash. Patients should immediately stop taking the medication if allergic reactions occur. For less serious reactions, they may continue consumption but everything should be reported to the doctor.
Patients with known hypersensitivity to Clindagel or lincomycin should not take the medication. The medication is also known to cause adverse reactions if it is taken together with erythromycin. People with a history of Crohns illness, asthma, eczema, allergies, colitis, intestinal disorder, kidney problem or liver illness should first consult their doctor to ensure safety. Clindagel is thought to have effects in-vitro so pregnant women, those trying to become pregnant as well as nursing mothers should seek consultation.
Clindagel has a bacteriostatic effect in which bacterial protein synthesis is interfered with through its binding action to bacterial ribosome particularly the 50S subunit. As the medication binds to the subunit, bacterial growth and spread is inhibited. Clindagel is absorbed from the gastrointestinal tract after which it will be delivered to various infection sites in the body.
20 patients suffering from Staphylococcus aureus skin infections were treated with 500 mg of Clindagel every 6 hours for 2 weeks. After the first week, 14 patients exhibited a lot of improvement and by the end of the second week, 19 patients had improved conditions. 8 patients were fully recovered. Only 3 of the patients showed mild allergic side effects such as skin pruritus and rash.
Clindagel is an over-the-counter or OTC medication, which can be bought at any pharmacy or clinic. The tablets usually come in 250 or 500 mg. Consumers should check the expiration date, manufacturer as well as brand name to ensure authenticity. When buying generic brands, it is important to only look for certified medication stores and online sites.
Clindagel overdose is also possible so patients should watch for signs and seek medical attention as soon as they notice symptoms. Take the missed dose as soon as one remembers but skip the missed dose if it is almost time to take the next. Be sure to store the medication at room temperature free from direct sunlight and moisture. Follow the instructions given by the doctor, especially if the medication is intended to be applied vaginally.
Clindagel has the following structural formula:
• Molecular formula of clindagel is C18H33ClN2O5S
• Chemical IUPAC Name is N-[2-chloro-1-(3,4,5-trihydroxy-6-methylsulfanyl-tetrahydropyran- 2-yl)-propyl]-1-methyl-4-propyl-pyrrolidine-2-carboxamide
• Molecular weight is 424.984 g/mol
• Clindagel available : 150mg capsules, 300mg capsules
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