Staphylococcus aureus has another medicament to worry about - Clindets. This antibiotic is one of the most effective without having to worry about hypersensitivity reactions. Though patients do have to learn proper use and observance of adverse effects.
Clindets is the generic name for the lincosamide antibiotic. It is used to treat infections caused by anaerobic bacteria and some protozoal diseases like malaria. Since it is highly effective against methicillin-resistant Staphylococcus aureus or MRSA infections, Clindets is used to treat acne. The medicament is available under the brand names Dalacin, Cleocin, Duac and Evoclin.
Clindets can be used to treat infections of the respiratory tract, pelvis, abdomen and vagina, peritonitis and septicemia. The medicament works well for patients with known hypersensitivity reactions to penicillins. Bone and joint infections from Staphylococcus aureus can also be treated with this medicament. The medicament is available in capsule form, taken orally. There are also lotions and gels applied topically for skin infections.
Serious side effects and allergic reactions include face and lip swelling, breathing difficulty, hives and rash, bloody or watery stool, fever, flu-like symptoms, body aches, nausea, vomiting, loss of appetite, jaundice, scanty or absent urine and headache. Mild or moderate side effects include mild nausea, stomachache, vaginal itching or discharge, throat irritation and mild skin itching or rash. Patients should immediately stop taking the medicament and seek immediate medical attention if they experience any symptoms of an allergic reaction. For mild to moderate side effects, patients may continue taking the medicament but everything should be reported to the physician.
Patients with hypersensitivity to Clindets or lincomycin should not take this medicament. This medicament is known to cause adverse reactions if it is taken with erythromycin. Patients with Crohns disease, asthma, eczema, allergies, colitis, intestinal disorder, kidney problem or liver disease should first consult their physician to ensure safety. Clindets is thought to have effects in-vitro so pregnant women, those planning to become pregnant and nursing mothers should seek their physician's advice before taking this medicament.
Clindets has a bacteriostatic effect meaning bacterial protein synthesis is interfered with through its binding action to bacterial ribosome particularly the 50S subunit. Since the medicament binds to the subunit, bacterial growth and spread is stopped. Clindets is absorbed from the gastrointestinal tract then delivered to various infection sites in the body.
In a study, 20 patients with Staphylococcus aureus skin infections were treated with 500 mg of Clindets every 6 hours for 2 weeks. After the first week, 14 participants exhibited a lot of improvement and by the end of the second week, 19 participants had improved conditions and 8 of the participants were fully recovered. Only 3 of the participants showed mild allergic side effects like skin itching and rash.
Clindets is an over-the-counter medicament, which can be bought at any pharmacy or drug store. The pills are available in 250 or 500 mg. Consumers should check the expiration date, manufacturer and brand name to ensure authenticity of the medicament. When buying generic brands, it is important to look for certified drug stores and online sites.
Clindets overdose is possible so patients should watch for signs and seek medical attention as soon as they notice any symptoms. If you miss a dose, take the missed dose as soon as remembered but skip it if it is almost time to take the next one. Store the medicament at room temperature free from direct sunlight and moisture. Follow the instructions from your physician, especially if the medicament is intended for vaginal use.
Clindets has the following structural formula:
• Molecular formula of clindets is C18H33ClN2O5S
• Chemical IUPAC Name is N-[2-chloro-1-(3,4,5-trihydroxy-6-methylsulfanyl-tetrahydropyran-2-yl)-propyl]- 1-methyl-4-propyl-pyrrolidine-2-carboxamide
• Molecular weight is 424.984 g/mol
• Clindets available : 150mg capsules, 300mg capsules
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