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Clinimycin


Clinimycin is one of the most effective lincosamide antibiotics used against staphylococcus aureus without having to worry about hypersensitivity reactions. Though patients have to learn proper use and observance of adverse effects.

This medication is used to treat infections caused by anaerobic bacteria and some protozoal diseases like malaria. Since it is highly effective against methicillin-resistant Staphylococcus aureus infections, Clinimycin is used to treat acne. The medication is available under the brand names Dalacin, Cleocin, Duac and Evoclin.

Clinimycin is used to treat infections of the respiratory tract, pelvis, abdomen and vagina, peritonitis and septicemia. The medication works well for patients with hypersensitivity reactions to penicillins. Bone and joint infections due to Staphylococcus aureus can also be treated with this medication. The medication is available in capsule form which is taken orally. There are also lotions and gels applied topically for skin infections.

Serious side effects and allergic reactions include face and lip swelling, breathing difficulty, hives and rash, bloody or watery stool, fever, flu-like symptoms, body aches, nausea, vomiting, loss of appetite, jaundice, scanty or absent urine and headache. Mild or moderate side effects include mild nausea, stomachache, vaginal itching or discharge, throat irritation and mild skin itching or rash. Patients should immediately stop taking the medication and seek immediate medical attention if they experience any symptoms of an allergic reaction. For mild to moderate side effects, patients may continue taking the medication but everything should be reported to the physician.

Patients with hypersensitivity to Clinimycin or lincomycin should not take this medication. This medication is known to cause adverse reactions if it is taken with erythromycin. Patients with Crohns disease, asthma, eczema, allergies, colitis, intestinal disorder, kidney problem or liver disease should first consult their physician to ensure safety. Clinimycin is thought to have effects in-vitro so pregnant women, those planning to become pregnant and nursing mothers should seek their physician’s advice before taking this medication.

Clinimycin has a bacteriostatic effect meaning bacterial protein synthesis is interfered with through its binding action to bacterial ribosome particularly the 50S subunit. Since the medication binds to the subunit, bacterial growth and spread is stopped. Clinimycin is absorbed from the gastrointestinal tract then delivered to various infection sites in the body.

In a study, 20 patients with Staphylococcus aureus skin infections were treated with 500 mg of Clinimycin every 6 hours for 2 weeks. After the first week, 14 participants exhibited a lot of improvement and by the end of the second week, 19 participants had improved conditions and 8 of the participants were fully recovered. Only 3 of the participants showed mild allergic side effects like skin itching and rash.

Clinimycin is an over-the-counter medication, which can be bought at any pharmacy or drug store. The tablets are available in 250 or 500 mg. Consumers should check the expiration date, manufacturer and brand name to ensure authenticity of the medication. When buying generic brands, it is important to look for certified drug stores and online sites.

Clinimycin overdose is possible so patients should watch for signs and seek medical attention as soon as they notice any symptoms. If you miss a dose, take the missed dose as soon as remembered but skip it if it is almost time to take the next one. Store the medication at room temperature free from direct sunlight and moisture. Follow the instructions from your physician, especially if the medication is intended for vaginal use.

Clinimycin has the following structural formula:

Chemical structure of clinimycin


• Molecular formula of clinimycin is C18H33ClN2O5S
• Chemical IUPAC Name is N-[2-chloro-1-(3,4,5-trihydroxy-6-methylsulfanyl-tetrahydropyran-2-yl)-propyl]- 1-methyl-4-propyl-pyrrolidine-2-carboxamide
• Molecular weight is 424.984 g/mol
Clinimycin available : 150mg capsules, 300mg capsules




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