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Evoclin


Evoclin is one of the most effective lincosamide antibiotics used against staphylococcus aureus without having to worry about hypersensitivity reactions, but patients do have to learn proper use and signs of adverse effects.

This medication is for infections caused by anaerobic bacteria and some protozoal diseases like malaria. As it is highly effective against methicillin-resistant Staphylococcus aureus infections, Evoclin is used to treat acne and is available under the brand names Cleocin, Duac and Evoclin.

Evoclin is used against infections of the respiratory tract, pelvis, abdomen and vagina, peritonitis and septicemia. The medication works well for patients with hypersensitivity reactions to penicillins. Bone and joint infections due to Staphylococcus aureus can also be treated with this medication. Evoclin is available in capsule form taken orally or in lotions and gels applied topically for skin infections.

Serious side effects and allergic reactions include face and lip swelling, breathing difficulty, hives and rash, bloody or watery stool, fever, flu-like symptoms, body aches, wamble, vomiting, loss of appetite, jaundice, scanty or absent urine and headache. Mild or moderate side effects include mild wamble, stomachache, vaginal itching or discharge, throat irritation and mild skin itching or rash. Patients should immediately stop taking the medication and seek immediate medical attention if they experience any symptoms of an allergic reaction. For mild to moderate side effects, patients may continue taking the medication but should report any side effects to the healthcare professional.

Patients with hypersensitivity to Evoclin or lincomycin should avoid this medication. This medication is known to cause adverse reactions if it is taken with erythromycin. Patients with Crohns disease, asthma, eczema, allergies, colitis, intestinal disorder, kidney problem or liver disease should first consult their healthcare professional to ensure safety. Evoclin is thought to have effects in-vitro so pregnant women, those planning to become pregnant and nursing mothers should seek their healthcare professional's advice before taking this medication.

Evoclin has a bacteriostatic effect meaning bacterial protein synthesis is interfered with through its binding action to bacterial ribosome particularly the 50S subunit. Since the medication binds to the subunit, bacterial growth and spread is stopped. Evoclin is absorbed from the gastrointestinal tract then delivered to various infection sites in the body.

In a study, 20 patients with Staphylococcus aureus skin infections were treated with 500 mg of Evoclin every 6 hours for 2 weeks. After the first week, 14 participants exhibited a lot of improvement and by the end of the second week, 19 participants had improved conditions of which, 8 of the participants were fully recovered. Only 3 of the participants showed mild allergic reactions like skin itching and rash.

Evoclin is an over-the-counter medication, which can be bought at any pharmacy or drug store. The tablets are available in 250 or 500 mg. Consumers should check the expiration date, manufacturer and brand name to ensure authenticity of the medication. When buying generic brands, it is important to look for certified drug stores and online sites.

Evoclin overdosage is possible so watch for signs and seek medical attention as soon as you notice any symptoms. If you miss a dosage, take the missed dosage as soon as remembered but skip it if it's almost time to take the next one. Store the medication at room temperature away from direct sunlight and moisture. Follow the directions from your healthcare professional, especially if the medication is intended for vaginal use.

Evoclin has the following structural formula:

Chemical structure of evoclin


• Molecular formula of evoclin is C18H33ClN2O5S
• Chemical IUPAC Name is N-[2-chloro-1-(3,4,5-trihydroxy-6-methylsulfanyl-tetrahydropyran-2-yl)-propyl]- 1-methyl-4-propyl-pyrrolidine-2-carboxamide
• Molecular weight is 424.984 g/mol
Evoclin available : 150mg capsules, 300mg capsules




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