Clonidin is a promising antihypertensive medication that can help patients deal with psychological bouts as well. The medication is effective in children with ADHD. Clonidin needs to be taken properly to maintain efficiency and safety.
Clonidin is an antihypertensive medication, which acts as an a2 adrenergic agonist. Generally used to treat hypertension by stimulating brain receptors in order to relax blood vessels in the body, it is also used to treat Tourette's syndrome, neuropathic pain, sleep hyperhydrosis and opioid detoxification. Clonidin can be used with stimulants to treat ADHD or attention-deficit hyperactivity disorder. Its effects on moderate ADHD-associated oppositional and impulsive behavior are helpful in managing tics.
Clonidin is also known by the brand names Catapres and Dixarit. It comes in a pill, an injectable via epidural and transdermal patches. Parasympathetic activity results through the central nervous system actions. Heart rate can significantly decrease with continued use of the medication. Other useful actions of Clonidin include treating migraine headaches, menopausal hot flashes, alcohol withdrawal symptoms, smoking cessation symptoms and ulcerative colitis.
The medication can result in side effects that are mild, moderate or severe. Your physician should be contacted immediately if any of these symptoms become severe: xerostomia, dizziness, drowsiness, fatigability, headache, costiveness, nervousness, decreased libido, upset stomach, rash and vomiting. Other serious side effects include fainting, slow or rapid heartbeat, arrhythmia, swollen feet or ankles and allergic symptoms like facial and lips swelling, breathing difficulty and hives. Orthostatic hypotension, xerostomia and tolerance to Clonidin may result.
Special precautions are taken with pregnant women and nursing mothers. Patients about to undergo surgery, including dental procedures, should inform their physician to avoid bleeding complications. Patients allergic to the medication should not take it and those with a history of kidney disease, heart attach, stroke and coronary artery disease should inform their physician first before taking Clonidin. The medication may cause adverse effects if the patient is also taking beta blockers, sleeping pills, and a number of supplements, vitamins and herbal medicines.
Clonidin acts as an a-adrenergic receptor agonist and has more affinity for a2 compared to a1. Brain receptors are selectively stimulated by the medication. These receptors are responsible for monitoring catecholamine levels in the blood. This stimulation causes the receptors to think that levels of catecholamine are higher than they are. The result is a reduction of catecholamine production and blood levels through relaxation and widening of blood vessels.
A survey of 35 children with FXS who were treated with Clonidin showed significant improvement in sleep disturbances, motor tics and hyperactivity. 63% of parents reported overall improvement in their child's condition, 20% reported minor improvement, 11% reported their child's condition became worse while 6% reported no noticeable effect. There were a number of exacerbated symptoms as well, including anxiety and sleep disturbances.
Clonidin is a prescription medication and should only be purchased from legitimate and verified pharmacies and physicians' clinics. The pills and patches are also available online but consumers should check the source and manufacturer first to ensure freshness and authenticity of the products.
Patients should watch out for symptoms of Clonidin overdose such as lethargy, lightheadedness, vomiting and drowsiness. The dose should be taken as prescribed by your physician. The medication should not be stopped abruptly even if the patient's condition becomes better. The medication may need to be taken for life by those patients suffering from chronic hypertension for maintenance. Store the medication at room temperature away from sunlight, heat and moisture.
Clonidin has the following structural formula:
Molecular formula of clonidin is C9H9Cl2N3
Chemical IUPAC Name is N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine
Molecular weight is 230.093 g/mol
Clonidin available : 0.1mg tablets, 0.2mg tablets, 0.3mg tablets
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