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Clozapin has proven to be useful in the discourse of schizophrenia. It tends to cause serious side effects if used improperly. Be sure to know the third-line discourse regimen to improve mood the right and safe way.


Clozapin is the generic name of the antipsychotic medicament that blocks a number of receptors for neurotransmitters. It is primarily used to treat schizophrenia symptoms in patients who have not shown adequate results from other medicaments. Clozapin belongs to a medicament class called atypical antipsychotics, which alters the activity of substances and chemicals in the brain. The medicament may appear under brand names like Clozaril, Gen-Clozapin, Fazaclo and Leponex.

The medicament comes in pill form and should be taken orally. It has a number of side effects that are considered lethal, which explains why it was categorized under third line discourse. Clozapin has been shown to be more helpful in treating schizophrenia symptoms compared to older antipsychotic medicaments. Other uses for this medicament include treating suicidal patients, paranoid individuals, manic patients, insomniacs and those suffering from schizoid personality, and dementia of the Lewy-body-type.


Drowsiness is the most common side effect of Clozapin. Patients may also experience increased heart rate, cephalalgia, weight gain, sleepiness, tremor, increased salivation, hypotension, fever, blurred vision, difficulty urinating, constipation and paralytic ileus. Some symptoms may disappear after being on the medicament for 2 to 3 days. Rarely, the medicament may also cause extrapyramidal effects or sudden involuntary movements of the extremities, eyes and head. One serious side effect of the medicament is agranulocytosis wherein white blood cell count drastically drops making the patient vulnerable to infection and other diseases. Other rare symptoms include seizures, myocarditis, jaundice, cardiomyopathy, pulmonary embolism, respiratory depression and chest pain. These should be reported right away.


Pregnant women and breastfeeding mothers should first consult their doctor before taking Clozapin. The medicament may interact with various medicaments like risperidone, cimetidine, epinephrine, quinidine, anti-seizure medicaments, phenytoin, sedatives, SSRIs or selective serotonin reuptake inhibitors and tranquilizers. Doctors should be fully informed about any herbal medicine or nutritional supplement that the individual is taking to avoid adverse reactions. Patients with known allergic reactions to the medicament are contraindicated. Individuals with a history of liver disease, kidney problem, lung problem, hypotension, leukemia, hypertension, glaucoma, diabetes and mental illness should take the medicament cautiously.

Clozapin acts by binding to serotonergic and dopamine receptors particularly dopamine at D1, D2, D3 and D5 receptors. It is also a 5-HT1A receptor partial agonist, which in turn improves mood. Furthermore, it acts as an antagonist at various adrenergic, histaminergic and cholinergic receptors. Once Clozapin is metabolized in the liver, it then binds to brain receptors improving dopamine and serotonin levels, which are responsible for mood. As a result patients will exhibit improvement from schizophrenic symptoms.


24 schizophrenic patients were given Clozapin for a span of 16 weeks. The initial dose was 25 mg a day during the first week and amounts were increased every two weeks until patients took around 400 mg during the last 2 weeks. During the first 4 weeks, 14 patients showed significant improvement in symptoms. Another 6 patients improved during the next 4 weeks until 21 out of 24 were shown to be stable at the end of the study. These patients were provided with Clozapin only after 2 other medicaments were rendered ineffective.

Clozapin is a prescription medicament and should only be purchased at legitimate pharmacies and clinics. There are sources that sell over the internet as well but consumers should make sure that these are authentic and certified. Consumers may ask for certification when buying online.


Avoid alcohol and tobacco products while taking Clozapin since these may decrease the effectiveness or exacerbate somnolence. Long-term use should also be monitored since tardive dyskinesia and agranulocytosis may result. Patients should expect results within the first 4 to 6 weeks but continuous improvements are possible over 6 months to 1 year.

Clozapin has the following structural formula:

Chemical structure of clozapin

 Molecular formula of clozapin is C18H19ClN4
 Clozapin available : 25mg tablets, 100mg tablets

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