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Cromoglycate


Cromoglycate, a mast cell stabilizer that prevents the release of inflammation-inducing chemicals including histamine, is used to control various conditions including asthma and allergic conjunctivitis.

CROMOGLYCATE ACTION

Cromoglycate is marketed as sodium cromoglicate and cromolyn sodium. This medication is available as a nasal spray under the brand names Nasalcrom and Rynacrom, which patients with allergic rhinitis can use. Patients with asthma buy this medication under the brand name Intal, while those who have allergic conjunctivitis can purchase it under the brand name Crolom, Opticrom, or Optrex. Patients with ulcerative colitis and mastocytosis purchase this medication under the brand name Gastrocrom.

Cromoglycate has been proven effective in reducing symptoms of food allergies, and in certain cases, chronic migraines.

CROMOGLYCATE DOSAGE

Dosages vary based on the condition being treated. For food allergies, this medication is usually prescribed to adults as 200 mg pills four times a day. The dosage is typically 100 mg for children. Dosage may be increased if the medication is not showing results after 2 weeks.

For patients with mastocytis, a 20 milligram dosage is usually taken 4 times a day. For patients with allergic conjunctivitis, Cromoglycate is usually administered by instilling 2 drops of a 4% solution spray four times a day.

Asthmatics may take Cromoglycate as a dry powder taking a 20 milligram dosage four times a day. For the aerosol, the dosage is 10 milligrams taken four times a day. In the event the condition does not improve, the dosage can be increased up to 8 times a day. Dosage can be lowered to 5 milligrams 4 times a day after the condition has improved.

CROMOGLYCATE SIDE EFFECTS

Patients may experience side effects including skin rashes, wamble, dizziness, headache, pain and skin edema in the joints, and unpleasant taste in the mouth. Patients may aggravate their asthma attacks, or suffer from pulmonary infiltrates. Patients may experience wheezing, nasal congestion, cough, and throat irritation especially after inhaling the dry powder. For patients using eye drops, there is a risk of stinging and burning in the eyes.

Patients may develop an allergic reaction to this medication. They are advised to immediately consult a physician if they experience symptoms of an allergic reaction including itching, rashes, skin edema, difficulty breathing and severe dizziness.

CROMOGLYCATE INTERACTIONS

Cromoglycate may interact negatively when taken with other medications. Patients should tell their physician if they are taking any other medications, whether prescription or non-prescription. Patients are also advised not to alter the dosage of Cromoglycate without the approval of their physician or pharmacist.

Patients using Cromoglycate for self-treatment should first clear with their physicians if they are experiencing any of these symptoms: pyrexia, sinus pain, discolored fluid discharged from the nose, and wheezing.

CROMOGLYCATE DURING PREGNANCY

Cromoglycate can affect pregnant women, but the chances are low. Patients should discuss the risks and the benefits of Cromoglycate with their physician before taking the medication.

Cromoglycate has the following structural formula:

Chemical structure of cromoglycate


 Molecular formula of cromoglycate is C23H16O11
 Chemical IUPAC Name is 5-[3-(2-carboxy-4-oxochromen-6-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylicacid
 Molecular weight is 468.3665 g/mol
 Cromoglycate available : 100mg tablets




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