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Cyklofosfamid, a cytotoxic medication and an immunosuppressive (it suppresses the immune system), is used to treat various types of cancer.

Cyklofosfamid is available under the brand name Cytoxan and comes in tablet form or a powder used for intravenous injection. It is for patients with certain types of cancer such as ovarian, breast, and leukemia and is also known to cure nephritic syndrome, an ailment of the kidneys among children.


The initial dose of Cyklofosfamid is a minimum 40 mg injected over 3 to 5 days divided into several doses. The standard dose for oral use is 1 to 5 mg/kg per day. It is then adjusted, if necessary, based on the tumor’s response to the medication and the side effects.


Cyklofosfamid is taken as prescribed by your healthcare professional. While taking this medication, drink more water, which will cause you to urinate more frequently. This will help the kidneys remove the medication from your system and lower the possibility of side effects.

Do not stop taking Cyklofosfamid until the prescribed period is over, even if you experiences nausea or vomiting.

This medication usually needs to be taken for a month, sometimes two, before seeing results. The results also depend heavily on the illness being treated.


The most common side effect is nausea so healthcare professionals usually prescribe another medication to reduce this symptom.

Patients may experience bleeding and inflammation of the bladder wall, or haemorrhagic cystitis characterized by blood in the urine. To reduce the chances of this, drink more water, preferably about 10 glasses a day.

This medication can affect the patient’s blood count, result in hair loss, irregular menstrual periods, and mouth ulcers. In case a patient develops any of these symptoms, he or she should immediately inform their healthcare professional.

Patients who come into contact with a person with chicken pox are advised to stop taking Cyklofosfamid and immediately consult their healthcare professional. This usually requires a special antiviral treatment since chicken pox can be severe to patients undergoing treatment with Cyklofosfamid.

Since Cyklofosfamid may affect the bladder and the blood, your healthcare professional may arrange for a blood and urine examination before allowing you to start taking Cyklofosfamid. Regular examinations are required while taking Cyklofosfamid. Patients should not take this medication unless they are undergoing regular blood and urine examinations.


Certain medications interact negatively with this medication. Patients should inform their healthcare professionals if they start any new medications while taking Cyklofosfamid.

Taking Cyklofosfamid may lead to a decrease in fertility. Patients are advised to use this medication with caution.


Pregnant women should not take this medication. Cyklofosfamid may be passed on to infants so breastfeeding mothers should not take this medication.

Cyklofosfamid has the following structural formula:

Chemical structure of cyklofosfamid

 Molecular formula of cyklofosfamid is C7H15C12N2O2P·H2O
 Chemical IUPAC Name is 2-[bis(2-chloroethyl)amino] tetrahydro-2H-13,2-oxazaphosphorine 2-oxide monohydrate
 Molecular weight is 279.1 g/mol
 Cyklofosfamid available : 25mg tablets, 50mg tablets

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