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Cyproheptadiene is a multi-use medicament that is prescribed mostly for patients with allergies, specifically hay fever, and patients suffering from anorexia. It relieves the sneezing, itching, bloating and watery eyes induced by most allergies. This medicament is an anti-histamine with antagonistic tendencies toward serotonin in the body. This means that this medicament stops the different chemicals in the body that cause allergic reactions, usually through blood flow control and blood vessel constrictions. The change in serotonin levels affects one's mood, so the anorexia is challenged by Cyproheptadiene through its antagonistic strategy against serotonin. Cyproheptadiene is also used to battle insomnia because of its unusually strong sedative effects as an anti-histamine.


Some common side effects of Cyproheptadiene are: nausea, vomiting, head aches, hypertension, diarrhea, chest pains, dry mouth, confusion, scratchy throat, and a loss of appetite. Serious side effects that may be a signal of an allergic reaction to the medicament include intense excitement, rashes, problems with vision, difficulty urinating, and weakness in the body. Proceed to your doctor immediately if any of these side effects occur. It might be best to bring Cyproheptadiene patients to a hospital if they show even the slightest signs of allergy to the medicament; it is better to be safe than sorry.


Before taking Cyproheptadiene there are some precautionary measurements that each person should take. First, your doctor must be informed of any medicaments, over the counter or prescription, which you are taking. Specifically, you should reveal if you are taking cold medicine, depression medicine, sleeping pills, muscle relaxants, narcotics and even vitamins. Second, you should inform your doctor about any diseasees you have previously contracted. Asthma, diabetes, hyperthyroidism, urinary tract disorders, heart disease, high blood pressure and seizures can all affect Cyproheptadiene and how it affects your body. Adult Cyproheptadiene users should remember that Cyproheptadiene specifically has a strong sedative effect so driving or operating machinery that can harm others is not suggested especially after first taking the medicament. Conversely, it has the opposite effect on young children. While adults may feel drowsy after taking Cyproheptadiene, children, especially very young children, tend to become excited and very active.


Mothers-to-be should be careful about using this medicament since it has not been proved safe for fetuses yet. There might be some risk of abnormalities in the fetus; however it has not been proven yet. It's better to inform your doctor and have him adjust the dosage or maybe give you another medicament. Nursing mothers should be careful too since this medicament might pass through the breast milk. It has been suggested that it would be better to stop breastfeeding while on Cyproheptadiene, since most medicaments are passed on in breast milk.


This medicament is marketed as Periactin and the dosage being administered varies according to the patient's age and body mass. For children, the dosages vary from 2- 16 mg a day. Adults may use 4-20 mg per day as prescribed by treating doctor. Patients are usually directed to take one pill during various times of the day. This is a medicament that can be taken without food.

Cyproheptadiene has the following structural formula:

Chemical structure of cyproheptadiene

 Molecular formula of cyproheptadiene is C21H21N
 Molecular weight is 287.398 g/mol
 Cyproheptadiene available : 2mg/5ml syrup, 4mg tablets

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