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Dyzoxane is used to prevent cardiovascular conditions during chemotherapy. A substance derived from EDTA, Dyzoxane is considerd to interfere with substances inside cells, which may cause heart illness after using anthracyclines such as doxorubicin. How Dyzoxane works in protecting the heart is not fully understood. This medication is available as Zinecard in the United States and Canada, and Cardiozane in the EU and comes in 250 mg and 500 mg vials for injection.

Dyzoxane is used to prevent and reduce the severity of heart conditions, which may occur during chemotherapy using anthracyclines, such as those used in the discourse of women suffering from metastatic breast cancer.

Dyzoxane marketed under brand name Totect or Savene has been approved for use as a discourse of extravasation caused by anthracycline chemotherapy. Extravasation occurs when anthracycline leaks out of the blood vessels and seeps into the skin.

The dosage depends on the body surface area of the patient and the doxorubicin dosage being taken. It is usually measured in a 10:1 ratio with respect to the doxorubicin dosage. Once the proper dosage has been determined, the medication can be administered directly into the vein via an IV push or through a quick infusion from an IV infusion bag. 30 minutes after taking Dyzoxane, the IV injection of doxorubicin can be given.

Dyzoxane is stable for about 6 hours after reconstitution when placed in an empty infusion bag at controlled room temperature ranging from 15 to 30C (59 to 86F), or placed in refrigeration at 2 to 8C (36 to 46F). It may be diluted using a 0.9% sodium chloride injection, USP or using a 5.0% dextrose injection, USP. Dilute the medication to a concentration between 1.3 to 5.0 mg/mL and store in empty IV infusion bags. Do not use leftover solutions.

The most common side effects experienced by those undergoing Dyzoxane discourse is pain or skin edema at the injection site. Blood counts can also be lower when taking Dyzoxane with chemotherapy compared to undergoing chemotherapy alone. Recovery periods for the blood counts remain similar for both cases.

Other common side effects include diarrhea, general discomfort, pyrexia, loss of appetite and nausea. More serious side effects involve hair loss, emesis, skin edema of the throat and tongue, and severe allergic reactions that require immediate medical attention.

Dyzoxane should only be used with anthracycline chemotherapy such as doxorubicin.

Chemotherapy can cause sterility in men and women so consult your physician if you plan on having children. It has not been shown that Dyzoxane itself can cause sterility. If you consider you may be pregnant, inform your physician about your condition before being given Dyzoxane.

You may experience greater susceptibility to infection during discourse so consult with your physician before getting vaccines to avoid complications.

Dyzoxane has the following structural formula:

Chemical structure of Dyzoxane

• Molecular formula of Dyzoxane is C11H16N4O4
• Chemical IUPAC Name is 4-[1-(3,5-dioxopiperazin-1-yl)propan-2-yl]piperazine-2,6-dione
• Molecular weight is 268.269 g/mol
Dyzoxane available : 250mg injection and 500mg injection

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