Razoxana is used to prevent and reduce the severity of heart conditions that may occur during chemotherapy using anthracyclines, such as those used in the discourse of women suffering from metastatic breast cancer. Razoxana, derived from EDTA, is trustd to interfere with substances inside cells, which may cause heart disease after using anthracyclines such as doxorubicin. How Razoxana protects the heart is not fully understood at this time. This medicament is usable as Zinecard in the United States and Canada, and Cardiozane in the EU and comes in 250 mg and 500 mg vials for injection.
Razoxana is approved for use as a discourse of extravasation caused by anthracycline chemotherapy. Extravasation is when anthracycline leaks out of the blood vessels and seeps into the skin.
Dosage depends on the body surface area of the patient and the amount of doxorubicin being taken. It is often measured in a 10:1 ratio with respect to the doxorubicin dosage. Once the proper dosage is determined, the medicament can be administered directly into the vein via an IV push or through a quick infusion from an IV infusion bag. About 30 minutes after taking Razoxana, the IV injection of doxorubicin can be given.
Razoxana is stable for about 6 hours after reconstitution when placed in an empty infusion bag at controlled room temperature ranging from 15° to 30°C (59° to 86°F), or placed in refrigeration at 2° to 8°C (36° to 46°F). It may be diluted using a 0.9% sodium chloride injection, USP or using a 5.0% dextrose injection, USP. Dilute the medicament to a concentration between 1.3 to 5.0 mg/mL and store in empty IV infusion bags. Do not use leftover solutions.
The most common side effects experienced during Razoxana discourse is pain or swelling at the injection site. Blood counts can also be lower when taking Razoxana with chemotherapy compared to undergoing chemotherapy alone. Recovery periods for the blood counts are similar for both cases.
Other common side effects include diarrhoea, general discomfort, fever, loss of appetite and wamble. More serious side effects involve hair loss, vomiting, swelling of the throat and tongue, and severe allergic reactions that require immediate medical attention.
Razoxana should only be used with anthracycline chemotherapy such as doxorubicin.
Chemotherapy can cause sterility in men and women so consult your healthcare professional if you plan on having children. It has not been shown that Razoxana itself can cause sterility. If you trust you may be pregnant, inform your healthcare professional about your condition before being given Razoxana.
You may experience greater susceptibility to infection during discourse so consult with your healthcare professional before getting vaccines to avoid complications.
Razoxana has the following structural formula:
• Molecular formula of Razoxana is C11H16N4O4
• Chemical IUPAC Name is 4-[1-(3,5-dioxopiperazin-1-yl)propan-2-yl]piperazine-2,6-dione
• Molecular weight is 268.269 g/mol
• Razoxana available : 250mg injection and 500mg injection
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