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Clarithromycin


Antibiotics are classified into different groups according to their strength in tackling bacteria and the illnesses that come with them. While Cefixim and Cephalexin are included in the milder group of cephalosporin antibiotics, Clarithromycin is in the stronger macrolide antibiotic side. As such, Clarithromycin is found useful in severe cases of infections in the lungs (pneumonia), the tubes that lead to the lungs (bronchitis), and in the skin. It is even helpful in controlling the spread of bacteria in cases of HIV/AIDS.

Clarithromycin was developed in Japan laboratories in 1970s. It was a byproduct of an invention of a different version of erythromycin gone wrong. More than a decade after, American company Abbott Laboratories created a partnership with the original manufacturer of Clarithromycin, Taisho, to earn its international rights. In 2004, the drug is made a generic brand in Europe and in the United States the following year, 2005.

Clarithromycin is usually taken by mouth in tablet and oral suspension forms. There is also a gel and lotion version of the drug, created for topical use. Intake or application of Clarithromycin is effective in preventing bacteria from growing and from spreading. It carries antimicrobial effects similar to erythromycin but is far more effective and safe. Clarithromycin, especially the tablet and liquid form will not cause discomfort even if taken on an empty stomach. It is easily absorbed and distributed into the site of infection. Using long-acting tablet, however, require to be taken with food.

A missed dose should be taken immediately after realizing it. If the realization is too close o your next schedule of intake, you may skip the missed dose and continue with your normal schedule. Never take a double dose of Clarithromycin. It is also not advisable to stop your intake of the medicine prematurely. Some symptoms may stop way before the bacteria are killed. Since your goal is to kill the bacteria and stop it from spreading, you will need to take it for the advised period of time. Following your doctor’s prescription is always important to keep you on the safe side.

Like any strong drug, Clarithromycin has its own set of side effects. Diarrhea, vomiting, and swelling on the face are common reactions of the body towards the treatment. In some cases, side effects could be severe and may include head ache, motion sickness, skin rashes, dry mouth, anxiety attacks, hallucinations, yellowish skin, and kidney failure. If any of these crops up, rush to your doctor immediately. Any side effect that does not appear normal or is causing you discomfort should be a cause for alarm.

Special precautions should be taken by those who have histories of allergy, asthma, hives, liver disease, kidney ailment, heart problem, or electrolyte imbalance. Clarithromycin is not recommended for patients with such cases as the reaction may be severe and life-threatening. When taking a prescription medicine like this, doctor’s advice is always needed. He will determine whether the drug is appropriate to your case or not and will regulate your intake to ensure that no damage is made to your important organs.

Clarithromycin has the following structural formula:

Chemical structure of clarithromycin


• Molecular formula of clarithromycin is C38H69NO13
• Chemical IUPAC Name is 6-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydropyran-2-yl)oxy-14-ethyl-12, 13-dihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yl)oxy- 7-methoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione
• Molecular weight is 747.953 g/mol
Clarithromycin available : 125mg/5ml suspension 100ml bottle, 250mg/5ml suspension 100ml bottle, 125mg/5ml suspension 50ml bottle, 250mg/5ml suspension 50ml bottle, 250mg tablets, 500mg tablets




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