Staphylococcus aureus has another great drug to worry about – clindamycin. This antibiotic is one of the most effective without patients having to worry much about hypersensitivity reactions. They do have to learn more about proper use and observance of adverse effects.
Clindamycin is the generic name of the lincosamide antibiotic. It is used for the treatment of infections caused by anaerobic bacteria as well as some protozoal disease like malaria. Since it is highly effective against methicillin-resistant Staphylococcus aureus or MRSA infections, clindamycin is also indicated for the treatment of acne. The drug also comes under the brand names Dalacin, Cleocin, Duac and Evoclin.
Clindamycin can also treat infections of the respiratory tract, pelvis, abdomen and vagina, peritonitis and septicemia. The drug is good for patients with known hypersensitivity reactions to penicillins. Bone and joint infections from Staphylococcus aureus can be treated as well. The medication comes in capsule form which should be taken orally. There are also lotions and gels to be applied topically for skin infections.
Various side effects have also been associated with the use of the medication. Examples of serious side effects are allergic reactions like face and lip swelling, breathing difficulty, hives and rash, bloody or watery stool, fever, flu-like symptoms, body aches, nausea, vomiting, loss of appetite, jaundice, scanty or absent urine and headache. Mild and moderate side effects include mild nausea, stomachache, vaginal itching or discharge, throat irritation and mild skin itching or rash. Patients should immediately stop taking the drug if allergic reactions occur. For less serious reactions, they may continue consumption but everything should be reported to the doctor.
Individuals with known hypersensitivity to clindamycin or lincomycin should not take the medication. The drug is also known to cause adverse reactions if it is taken together with erythromycin. People with history of Crohns disease, asthma, eczema, allergies, colitis, intestinal disorder, kidney problem or liver disease should first consult their doctor to ensure safety. Clindamycin is thought to have effects in-vitro so pregnant women, those trying to get pregnant as well as nursing mothers should seek consultation.
Clindamycin has a bacteriostatic effect in which bacterial protein synthesis is interfered through its binding action to bacterial ribosome particularly the 50S subunit. As the drug binds to the subunit, bacterial growth and spread is inhibited. Clindamycin is absorbed from the gastrointestinal tract after which it will be delivered to various infection sites in the body.
20 patients suffering from Staphylococcus aureus skin infection were treated with 500 mg of clindamycin every 6 hours for 2 weeks. After the first week, 14 patients exhibited a lot of improvement and by the end of the second week, 19 patients have improved conditions. 8 patients were fully recovered. Only 3 of the patients showed mild allergic side effects such as skin itching and rash.
Clindamycin is an over-the-counter or OTC drug which can be bought at any pharmacy or clinic. The tablets usually come in 250 or 500 mg. Consumers should check the expiry date, manufacturer as well as brand name to ensure authenticity. When buying generic brands, it is important to only look for certified drugstores and online sites.
Clindamycin overdose is also possible so patients should immediately watch for signs and find help as soon as they notice. Take the missed dose as soon as one remembers but skip the missed dose if it is almost time to take the next. Be sure to store the drug in room temperature free from direct sunlight and moisture. Follow the right instructions given by the physician if the drug is intended to be applied vaginally.
Clindamycin has the following structural formula:
• Molecular formula of clindamycin is C18H33ClN2O5S
• Chemical IUPAC Name is N-[2-chloro-1-(3,4,5-trihydroxy-6-methylsulfanyl-tetrahydropyran-2-yl)-propyl]- 1-methyl-4-propyl-pyrrolidine-2-carboxamide
• Molecular weight is 424.984 g/mol
• Clindamycin available : 150mg capsules, 300mg capsules
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