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Desloratadine is mainly used for battling allergies of any kind. Usually a popular choice among doctors because of its non-drowse effect, it is marketed under many names but mainly under NeoClarityn, Claramax, Clarinex and Aerius. Desloratadine is an antihistamine classified as tricyclic. Other tricylic anti histamines include includes loratadine, also known as Claritin, cetirizine or Zyrtec, and azelastine or Astelin. Histamine is a common medical term, and it is actually a chemical that activates cells which in turn trigger effects like rashes, watery eyes, sneezing and itchiness (symptoms that usually indicate an allergy). It does not cause drowsiness like other anti-histamines because it does not enter the central nervous system, more specifically the brain, from the blood. It simply prevents the activation of the cells that cause allergy by stopping the histamine from activating that particular cell.

Desloratadine has many side effects that are common to anti-histamines. Fatigue, dry mouth, headaches, sore throat and mouth, difficulty urinating, muscle pain, exhaustion, trouble with menstruation, difficulty sleeping, and stomach problems are some of the more typical side effects. Usually these side effects are manageable and even negligible. An allergic reaction to this drug usually manifests itself in difficulty with breathing. It is important to se a doctor immediately if this occurs. A common side effect that most people don’t notice is sensitivity to sun, so be careful and take special care of your skin while out in the sunlight when you are on Desloratadine.

Desloratadine is similar to many anti-histamines so please inform your doctor if you are allergic to any anti-histamine. Chances are you might be allergic to Desloratadine too. Also inform your doctor if you are allergic to loratadine, more commonly known as Claritin. It is also important to inform your doctor of any medication that you are taking before you start taking new medication. Prescription and over the counter medication, nutritional supplements, herbal products and other medication should be disclosed to your doctor. Also inform your doctor if you have had a liver disease or a kidney disease or porphyria. This drug affects both those organs so if they are sensitized from a former disease your doctor should be made aware of it.

Another precaution patients should take is with pregnancy. Women who take Desloratadine should be aware that this drug has not been thoroughly tested yet. It would not be advisable to take the drug without telling your doctor that you are pregnant. It might cause some abnormalities with the fetus as well as cause problems with the mother. So women who are pregnant, and women who become pregnant during the course of the treatment should inform their doctors. Nursing mothers should also be aware that this drug is passed through the milk, so they should stop nursing while on the treatment or maybe their doctor can recommend another drug that will be less harmful to the baby.

Desloratadine is available in tablet form, and it is most popularly marketed as Clarinex. Patients are advised to follow specifically their doctors’ instructions. Keep medications in a cool place out of direct sunlight.

Desloratadine has the following structural formula:

Chemical structure of desloratadine

• Molecular formula of desloratadine is C19H19ClN2
• Molecular weight is 310.82 g/mol
Desloratadine available : 5mg tablets, 10mg tablets

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