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Indomethacin


Indomethacin is an NSAID. A non-steroidal anti-inflammatory drug that was marketed worldwide under the trade names Indocin, Indocin SR, Indocid, and Indochron ER among others. It is primarily used to alleviate pain, swelling, stiffness, and tenderness caused by various conditions including Rheumatoid Arthritis, Osteoarthritis, and Ankylosing Spondylitis. It works by stopping the production of substances that causes the symptoms.

Although Indomethacin is an effective pain reliever, special warnings are out to alert patients that a greater risk of suffering from stroke and heart attack are likely to occur in relation to medication use. NSAIDs apart from Aspirin have been found to cause such symptoms especially after a long-term of use. To ensure safety, patients must take all the precautions necessary. First and foremost, inform your doctor about your entire medical history. This includes possible allergic reactions you might develop upon using Indomethacin. Your existing use of other medicines must also be discussed to ensure that the possibility of encouraging drug interactions is out of the picture. Previous and existing conditions that you have contracted should also be taken into light. Tell your doctor if you have had histories of stroke, heart surgery, heart ailments, high cholesterol, hypertension, and diabetes. Smokers must also be given special attention when prescribed with Indomethacin. The issue of pregnancy, as with most medicines, is also a top concern. Women must also ask their doctors if it is safe to breastfeed their newborns while they are under Indomethacin treatment.

Indomethacin comes in many forms including tablets, capsules, controlled-release capsules, liquid suspensions, and suppositories. The tablet, capsule, liquid suspension and suppository forms are used two to four times daily while the controlled-release capsules are used one to two times daily. Indomethacin is also available in spray or gel forms to be applied at the specific area of affliction. Always follow your doctor’s prescription carefully. Take your medicines on schedule and never alter that schedule so you can enjoy most of Indomethacin’s benefits without increasing your risk from harsh side effects.

The use of Indomethacin unfortunately comes with numerous risk factors. Side effects are likely to occur at any time during your treatment. Some of the problems like drowsiness, dizziness, diarrhea, constipation, and vomiting are quite bearable. However, you must be alert with the occurrence of severe, more serious side effects like unusual bleeding or bruising, blisters, fever, irregular heartbeat, bloody stool and urine, blurred vision, and lack of energy among others. Such symptoms need immediate medical attention and must be consulted with your doctor.

Patients under Indomethacin treatment are usually required to attend regular appointments with their doctor. From time to time, your doctor would request a series of clinical tests to ensure that you are safe with the drug. Blood tests will keep your chloride, sodium, and potassium levels in check as well as your renal function. The use of Indomethacin, especially alongside an ACE inhibitor, can cause serious damage to your kidney so it is important that you are under close monitoring while taking the medication. Such examinations are not necessary for patients who are using Indomethacin spray or gel.

Indomethacin has the following structural formula:

Chemical structure of indomethacin


• Molecular formula of indomethacin is C19H16ClNO4
• Chemical IUPAC Name is 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetic acid
• Molecular weight is 357.787 g/mol
Indomethacin available : 25mg capsules, 50mg capsules




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