Accolate is an asthma medication in a class of medications known as leukotriene receptor antagonists, or LTRA’s. It works by blocking the production of certain substances that provoke the symptoms of an asthma attack, such as coughing, wheezing, shortness of breath, and tightness in the chest. It is a prophylactic medication used for the prevention of asthma attacks, and is not intended to be used to treat attacks that are going on at the time. Accolate is also sometimes used to treat allergic rhinitis, which includes hay fever, runny nose, watery eyes, or other allergy symptoms) Accolate is taken as a tablet twice a day, but it might take several weeks before your asthma symptoms improve significantly. You should be sure to take Accolate on an empty stomach, either one hour before or two hours after a meal, since food can change the way your body processes this drug.
Accolate may cause headaches, but they should not be severe. If you do experience a severe headache, or one that does not go away, you should call your doctor immediately. Other serious symptoms include nausea, rash, difficulty breathing or swallowing, infections, weakness, back pain, vomiting, numbness or tingling in the hands or feet, loss of appetite, fatigue, itching skin, flu-like symptoms, brown or dark urine, sore throat, indigestion, swelling of the eyes, face, lips, tongue, or throat, or hoarseness. If you experience any of these when taking Accolate, you should also notify your doctor immediately. Another very rare side effect of Accolate is hepatic dysfunction, so you should contact your doctor if you experience pain in the upper right quadrant of the abdomen, nausea, fatigue, lethargy, itchy skin, jaundice, and anorexia. In very rare cases you might also experience a condition called systemic eosinophilia or eosinophilic pneumonia, which is expressed as rash, a worsening of your asthmatic symptoms, heart complications, and nerve disorders. In most cases, reducing your dosage can relieve these symptoms.
Some medications should be used very cautiously with Accolate. If you are taking blood thinners such as Warfarin, you should be monitored very carefully while you are on both medications, and you may need to have your Warfarin dosage adjusted. Make sure to tell your doctor if you are taking aspirin, tolbutamide, erythromycin, theophylline, carbamazepine, phenytoin, or corticosteroid therapy. You should also make sure your doctor knows about any over the counter or herbal medications you take, since these substances can change the way you process medication.
Accolate is in Pregnancy Category B, which means that it can be taken by pregnant women and not cause harm to the developing fetus. It is known to be excreted in breast milk, and because it is not suitable for infants, if you are taking it you should not breast feed your baby. Accolate is safe for children 5 years of age and older, with a modified dosage. Older people should be observed carefully when taking Accolate, since they may process medications differently.
Accolate has the following structural formula:
• Molecular formula of accolate is C31H33N3O6S
• Chemical IUPAC Name is cyclopentyl [3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]- 1-methyl-indol-5-yl]aminoformate
• Molecular weight is 575.676 g/mol
• Accolate available : 200mg tablets
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