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Combaren is a medication that is made from a combination of codeine and declofenac. It is a pain reliever, and is also used to relieve swelling and inflammation, stiffness of the muscles and joints, such as that caused by arthritis and gout, pain after surgery, anklosing spondyltis, or soreness resulting from childbirth. It is also used regularly to treat different kinds of arthritis, menstrual cramps, and other causes of pain or tenderness. It belongs to a class of drugs known as NSAIDs or non-steroidal anti-inflammatory drugs.

Some of the more common side effects of Combaren can include dizziness, diarrhea, headache, heartburn, gas or bloating, or constipation. You should let your doctor know if those effects are very serious or do not go away. Other side effects might be very serious, but these are rare. Contact your doctor immediately if you experience black or tarry stools, bloody stool or vomit, vomiting material that looks like coffee grounds, tinnitus, blurred vision or changes on the way you see colors, confusion, fever, pale skin, unexplained weight gain, excessive fatigue or sleepiness, low energy, pain in the right side of the abdomen, yellowing of the skin or the white of the eyes, flu-like symptoms, or rash. If you experience swelling of the hands, feet, face, lips, tongue, or throat, difficulty breathing or swallowing, or a breakout of hives, you may be having an allergic reaction and should seek emergency help immediately.

As with many NSAIDs, Combaren can cause irritation to the stomach. In some cases, ulceration, bleeding, or perforation of the stomach or intestinal lining can result. That risk is increased for the elderly and for those taking high doses. If you are sensitive to NSAIDs, or if you have a history of stomach problems, your doctor may want to monitor you to make sure you are reacting well to the medication. In some cases, you may be prescribed an additional medication to help protect your stomach from irritation or damage.

Some people should use extreme caution when taking Combaren. If you have liver disease or kidney disease, heart failure, if you are taking diuretic medications or recovering from major surgery, your doctor should make sure your kidneys are working as they should be before allowing you to be treated with Combaren. In rare cases, Combaren can cause Stevens-Johnson syndrome, which can result in serious blistering or peeling of the skin. If this happens, you should stop taking Combaren immediately and contact your doctor. If you have asthma, high blood pressure, a blood clotting disorder that requires you to take anti-coagulants, or connective tissue disease such as lupus, you should consult your doctor before taking Combaren.

Combaren is not considered safe during pregnancy, especially in the first and third trimesters. When taken in the third trimester, it can increase the length of labor and sometimes cause complications for the baby. This medication does pass into breast milk, but at normal doses it is unlikely to harm a baby. Always let your doctor know if you are breastfeeding or plan to do so.

Combaren has the following structural formula:

Chemical structure of combaren

• Molecular formula of combaren is C14H11Cl2NO2
• Chemical IUPAC Name is 2-[2-(2,6-dichlorophenyl)aminophenyl]ethanoic acid
• Molecular weight is 296.148 g/mol
Combaren available : 50mg tablets

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