Noctamid is a brand name for lormetazepam, a medication used for the short-term treatment of severe insomnia. It is available in the United Kingdom, but is not approved for use in the United States or Canada. It is part of a class of medications known as hypnotic benzodiazepine, and is given in tablets.
One of the most serious side effects of Noctamid is its potentially adverse effect on memory functions. Other side effects of Noctamid include sleepiness, dizziness, muscle weakness, partial amnesia, lightheadedness, low blood pressure, digestive disturbances, difficulty speaking, increase or decrease in sex drive, inability to empty the bladder or to control it, jaundice, rash, increased aggression, confusion, lack of coordination, headache, increased salivation or dry mouth, changes in vision, tremor, and dependence, including withdrawal symptoms when treatment is stopped. You may also experience residual effects the next day, what is known as a medication hangover, which may result in slower reflexes and impaired thinking ability.
The risk for developing dependence is low when Noctamid is used as it is intended, for two to four weeks only. If you have a history of addiction or dependence, you may be at higher risk for dependence if you take Noctamid. If you start to develop dependence, you may experience withdrawal symptoms when your treatment ends. These symptoms can include rebound insomnia, nightmares, depression, inability to concentrate, feelings of unreality, inability to think clearly, tingling or numbness in the hands and feet, restlessness or nervousness, sweating, anxiety, panic attacks, malaise, upset stomach, emotional instability, ringing in the ears, tremor, weakness, and stiffness of the muscles. Stopping your medication abruptly can result in even more serious withdrawal symptoms such as seizures and hallucinations.
Certain people should be very cautious in taking Noctamid. If you have a respiratory disease, if you are elderly, if you have a history of addiction, kidney disease, genetic blood diseases, mental health problems, liver disease, or muscles weakness, you should be very closely monitored while taking Noctamid. Others should not take Noctamid at all, including those who have had a sudden worsening of any lung disorders, a sudden onset of muscle weakness, children, obsessive disorders, sleep apnea, or those being treated for chronic psychosis. You should not take this medication if you are planning to drive or operate machinery.
Some medications will increase the effects of Noctamid, including alcohol and certain antihistamines. You should also be cautious in taking Noctamid with clozapine, since it can cause your blood pressure and breathing rate to drop, which could lead to a loss of consciousness.
Noctamid should not be used if you are pregnant. It may be harmful to a developing baby and may cause complications in the pregnancy. This is most important during the third trimester of a pregnancy and prior to labor. It is also known that Noctamid passes into breast milk, and nursing mothers are advised to avoid using this drug while they are breastfeeding. As with all medications that you take during pregnancy and nursing, check with your doctor about what is safe.
Noctamid has the following structural formula:
• Molecular formula of noctamid is C16H12Cl2N2O2
• Chemical IUPAC Name is 9-chloro-6-(2-chlorophenyl)-4-hydroxy-2-methyl-2,5- diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-3-one
• Molecular weight is 335.2 g/mol
• Noctamid available : 0.5mg tablets, 1mg tablets, 2mg tablets
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