Terbinafine, or Terbinafine hydrochloride, is a generic name for an anti-fungal antibiotic medication that also goes under the names of Lamisil, Terbisil, and Zabel. It comes in tablets or as a topical cream for the treatment of onychomycosis, which is a fungal infection of the fingernails and toenails. It is necessary to have the fungus from beneath the nails tested before treating someone for onychomycosis. Terbinafine tablets are taken once a day for a course of treatment lasting six weeks if you have a fingernail fungus, and for twelve weeks if you have a toenail fungus. The nail is fully healed after the fungus has cleared up and a healthy length of nail has had a chance to grow. Terbinafine can also be used on other types of fungal infection including jock itch, athlete’s foot, and ring worm as well as fungal infections sometimes present in children’s scalp.
The most frequently reported side effects of Terbinafine tablets are headache, diarrhea, heartburn, abdominal pain, rash or itching skin, nausea, flatulence, taste disturbances, visual disturbances, and abnormalities in the liver enzymes. Other side effects are far more rare, but also more serious, and can include liver injury or failure, serious adverse reactions of the skin, hives, taste loss, malaise, fatigue, hair loss, pain in the joints, pain in the muscles, vomiting, and excessive weight loss. In very rare cases, you may experience liver failure so severe that a transplant in required; this can happen whether you have an underlying liver condition or not.
Because of the serious possible side effects centering on the liver, Terbinafine is not recommended for anyone who has any kind of liver disease, either chronic or active. Your doctor should assess the condition of your liver before you are treated with Terbinafine. If you begin Terbinafine treatment, you should be very attentive to the presence of side effects such as nausea, loss of appetite, fatigue, vomiting, pain in the upper right side of the abdomen, jaundice, dark urine, or pale stools. If you do experience any of these, you should immediately cease taking Terbinafine and contact your doctor immediately.
You should let your doctor know if you have any kidney or liver disorders, or if you suffer form an autoimmune disorder such as lupus or psoriasis. Treatment with Terbinfin can exacerbate those conditions or require an adjustment to the dosage you are able to take.
Terbinafine is in Pregnancy Category B, which means that extensive animal testing has not indicated that this drug will harm a developing fetus or complicate a pregnancy. However, since no studies have been done on human women, you and your doctor should be cautious in initiating Terbinafine treatment during pregnancy. Treatment for onychomycosis can wait until after pregnancy, so you should consider delaying treatment if this infection occurs. Terbinafine does pass into breast milk, so it is not recommended for nursing mothers. It has not been evaluated for children except in specific circumstances, so pediatric use is not generally recommended.
Terbinafine has the following structural formula:
• Molecular formula of terbinafine is C21H25N
• Chemical IUPAC Name is N,6,6-trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine
• Molecular weight is 291.43 g/mol
• Terbinafine available : 250mg tablets
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