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Phenoxybenzamine


Hypertension or high blood pressure can be a debilitating disease if not treated. Its occurrence may cause physical discomfort that could hinder your normal daily activities. Although hypertension rarely shows off recognizable symptoms at the onset, the appearance of one or two should already be an alarming incident. Hypertension is a serious problem that could lead to heart stroke, heart failure, renal disease, and retinal damage.

When your blood circulation is challenged, it prompts the heart to work hard in pumping the blood around. This kind of activity can lead to serious health problems when left untreated. That is why a medication treatment that normalizes the blood pressure is significant. Alpha blockers, like Phenoxybenzamine, are useful for this purpose.

Phenoxybenzamine is a prescription medicine that is sold worldwide under the brand name Dibenzyline. It is mostly prescribed to hypertensive patients whose condition is brought about by pheochromocytoma or a neuroendocrine tumor. Among drugs with similar effects, Phenoxybenzamine is considered as the most efficient in the long run. Its extended effect offers the best quality of relief for the symptoms of hypertension.

Phenoxybenzamine is also the first alpha blocker drug that is used for the treatment of benign prostatic hyperplasia. Phenoxybenzamine treatment in this sense is rarely advised, however, due to the unwanted adverse effects that come with it.

Prior to Phenoxybenzamine prescription, you need to discuss several factors with your doctor to ensure that you are safe with the medicine. Allergy with the drug, to its components, or to other drugs must be established. Phenoxybenzamine may also cause drug interactions so you will need to tell your doctor all about the drugs you are using including vitamins and herbal supplements.

Phenoxybenzamine is used with caution to patients who has a history of heart ailments and kidney disease. In this case, an adjusted dosage or a different medicine altogether may be needed. The use of Phenoxybenzamine as a treatment is contraindicated to pregnant and lactating women with the possible risks that it can bring to an unborn or nursing child.

As with any other drug, the use of Phenoxybenzamine also comes with unwanted effects. The symptoms of side effects are usually mild and temporary. With Phenoxybenzamine treatment, they are characterized by dizziness, drowsiness, nasal congestion, upset stomach, and sexual dysfunction. If any of your symptoms persist, worsen or came with chronic vomiting, abnormal heartbeat, and fainting, you obviously need prompt medical attention.

Since Phenoxybenzamine can cause dizziness and drowsiness, you need to be careful when doing activities that need alertness while you are under treatment. Go back to your normal routine as driving a car or operating a machine only when you become fully adjusted to such an effect. It would also help a lot if you avoid alcohol intake while you are using Phenoxybenzamine. Alcohol can only worsen your symptoms of drowsiness and dizziness. Be careful when you are rising from a sitting or lying position. An abrupt movement may make you fall, especially when you are already drowsy or dizzy from Phenoxybenzamine.

Phenoxybenzamine has the following structural formula:

Chemical structure of phenoxybenzamine


• Molecular formula of phenoxybenzamine is C18H22ClNO
• Chemical IUPAC Name is N-benzyl-N-(2-chloroethyl)-1-phenoxy-propan-2-amine
• Molecular weight is 303.826 g/mol
Phenoxybenzamine available : 10mg tablets




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