Original: http://www.medicalook.com/reviews/Nootropil.html


People finally have a way of slowing down brain and cognitive deterioration with the use of Nootropil. The medication is truly advantageous since it presents zero toxicity and very minimal side effect risk.

Nootropil is the generic name of the nootropic which is a derivative of GABA or gamma-aminobutyric acid, a neurotransmitter. It also comes under the brand names Nootropil, Oropi, Myocalm and Dinagen prescribed to treat conditions such as cortical myoclonus, dementia, vertigo, dyslexia and sickle cell anemia. There are several claims regarding the supplement such as enhancement of memory and cognition, boosting of blood and oxygen flow to the brain, improvement of Down Syndrome and Alzheimer’s Disease and slowing down of brain aging. Nootropil comes in the form of pills which should be taken orally.

Nootropil can cause a variety of side effects like headache, general excitability, insomnia, irritability, headache, anxiety, nervousness, agitation, tremors, nausea, gastrointestinal distress and dizziness. Nootropil is not known to cause overdose side effects.

Contraindications to the medication include hypersensitivity and allergic reaction to it as well as those who may have renal disorder. Individuals with liver impairment, cerebral hemorrhage and under 16 years of age are also prohibited from taking Nootropil. Special precaution should be given to those with underlying hemostatis disorders and who had just undergone a major surgery or severe hemorrhage. Elderly patients are also provided with special caution since many already have diminished renal function.

The true mechanism of action of Nootropil is unknown. However, it is believed to act on ion carriers or ion channels in order to increase the excitability of neurons non-specifically. The medication increases blood and oxygen flow to different parts of the brain and improves the function of acetylcholine which is a brain neurotransmitter through muscarinic cholinergic receptors. It may also have slight effects on NMDA glutamate receptors and boosts cell membrane permeability thereby improving symptoms of various cognitive disorders.

24 patients were tested for Nootropil side effects in the clinical study. Half of the group took 800 mg of the medication 3 times daily for 4 weeks while the rest were placed on a placebo. At the end of the study, the Nootropil group showed mild or no side effects compared to the placebo group. The results showed that it can truly render beneficial effects with minimal risk for side effect development.

Nootropil is available in most pharmacies, health stores and online drugstores. It is important to verify freshness and quality by looking up the source, expiry date and manufacturing company. It may also be available in bulk from nutritional suppliers and sold in powder form. Make sure you only buy from legitimate sources to ensure safety and efficacy.

Although there is no known toxic effects, Nootropil should be taken only in the recommended dosage. Store the medication in a tightly sealed container away from sunlight, moisture and children’s reach. Side effects should be reported immediately. Caffeine may have an effect on its true usefulness. When used with other drugs, determine your body’s response to know which combination is best.

Nootropil has the following structural formula:

Chemical structure of nootropil

• Molecular formula of nootropil is C6H10N2O2
• Chemical IUPAC Name is 2-oxo-1-pyrrolidineacetamide
• Molecular weight is 142.16 g/mol
Nootropil available : 400mg tablets, 800mg tablets

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