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Piribedil


People having problems with cognition and Parkinson’s Disease may now rely on Piribedil to alleviate their symptoms. Make sure you know the right way to take the drug to avoid complications and side effects.

Piribedil is the D2 agonist which is mainly used to treat Parkinson’s Disease. It acts by stimulating dopamine receptors thereby alleviating various symptoms like tremors. It is also used to treat other conditions like circulatory problems due to its D2 antagonistic effects. The drug also comes under the brand name Trivastal that comes in the form of extended-release capsules which should be taken by mouth. Piribedil can be used as monotherapy or together with L-dopa therapy in early and advanced Parkinson’s Disease. A lot of elderly patients have benefited because of its relative effects in cognition such as treating impaired memory, attention and focus.

Just like any other drug, Piribedil can cause different side effects. Common ones to expect would be nausea, dizziness, confusion and vomiting. Rare side effects that need to be reported immediately include minor gastrointestinal problems like vomiting, flatulence and nausea among predisposed individuals. Other uncommon symptoms may include orthostatic hypotension or drowsiness in predisposed persons.

Contraindciations for Piribedil include known hypersensitivity or allergic reaction to the drug, history of cardiovascular disease and myocardial infarction. Those with underlying conditions or predisposition to cardiovascular problems and cardiogenic shock should also take caution. Special precautions are given to pregnant women and nursing mothers.

Piribedil works by stimulating dopamine receptors present in the brain which in effect treats the deficit of the postsynaptic D2 and D3 receptors of the mesolimbic and mesocortical pathways. The drug also has vasodilating effects thereby improving different cognitive symptoms and reinforces noradrenergic transmission resulting to improvement in focus, attention and memory.

42 Parkinson’s Disease patients were included in a study testing for the relative effects of Piribedil. Half of the patients took 50 mg of the drug 3 times a day while the other half were placed on a placebo for a duration of 6 weeks. At the end of the study, those who were placed on Piribedil showed a lot of improvement in terms of focus and alleviation of tremors. Researchers concluded that Piribedil is truly an effective medication in treating Parkinson’s Disease as well as a few other cognitive disorders.

Piribedil is available in most drugstores, doctor’s clinics and online pharmacies. Check for product authenticity and freshness by reading the label and source properly. Find out that the source truly exists contacting the numbers and location provided. When buying online, also consider the source that it is truly verified and legitimate in selling pharmaceutical products.

Do not take Piribedil unless advised by your doctor. Make sure you store the drug in a tightly sealed container away from moisture, sunlight and children’s reach. Do not double the dose if you miss one but take the next one when it is due. Make sure you inform your doctor all underlying conditions and current medications and supplements you’re taking to avoid complications.

Piribedil has the following structural formula:

Chemical structure of piribedil


• Molecular formula of piribedil is C16H18N4O2
• Chemical IUPAC Name is 2-[4-(benzo[1,3]dioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
• Molecular weight is 298.340 g/mol
Piribedil available : 50mg tablets




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