With a generic name of Pregabalin, Lyrica is a type of oral drug that is related chemically to Gabapetin medications such as Gabarone and Neurontin. Lyrica is used for the treatment of pain brought about by neurological ailments like postherpetic neuralgia and seizures. It is likewise used for the treatment of fibromyalgia. There is no know mechanism action of Lyrica. The drug binds to channels of calcium on the nerves and can adjust the discharge of neurotransmitters in the body, or those chemicals that nerves use in communicating with each other. Reduced communication between the nerves can contribute to the effect of Lyrica on pain and seizures. The Food and Drug Administration approved this drug in December of 2004.
Lyrica comes in tablets from 25 up to 300 milligrams. It should be stored at room temperature, preferably from 15 up to 30 degrees Celsius.
Lyrica can be taken on an empty stomach. Doctors usually recommend a dosage of 50 milligrams thrice a day or 150 milligrams in a day. The dose can be then increased up to 100 milligrams thrice a day or 300 milligrams per day after a week of use.
For individuals suffering from postherpetic neuralgia, doctors usually recommend a starting dose of 75 milligrams of Lyrica taken twice per day, or 50 milligrams of the drug taken thrice per day. The said dose may be increased up to 300 milligrams in a day after a week of use. If pain persists after 2-4 weeks of continued treatment at 300 milligrams of Lyrica per day, the dose may be then increased to 300 milligrams taken twice per day, or a milder dose of 200 milligrams for three times in a day. Doses that are greater than 300 milligrams may result to serious side effects.
For those suffering from seizures and related pain, dosage is usually at 150 up to 600 milligrams in a day divided into at least 2 doses.
Fibromyalgia is commonly treated with a dosage of 300 to 450 milligram per day that is divided into at least 2 doses.
Use of alcohol and drugs that can cause sedation may result to the sedative effects of Lyrica. Drugs such as rosigitazone and Pioglitazone can cause gain in weight when taken with Lyrica, as well as fluid retention and in some cases, heart failure. Thus patients should consult with their physicians about the risks of taking Lyrica with the abovementioned medications.
There is no adequate study proving that the use of Lyrica is dangerous among pregnant women. However it would be best to consult first with a doctor if the patient is pregnant or planning to get pregnant.
Some of the more common side effects of Lyrica include dizziness, edema or accumulation of fluid, dry mouth, blurred vision, unexplained gain in weight, and difficulty in concentrating. Other side effects may also include reduced count of blood platelet and increase in the creatinine kinase levels of the body. The latter can be a sign of injury of the muscles. Patients are advised to consult their doctor in case any of these side effects persist.
Lyrica has the following structural formula:
• Molecular formula of lyrica is C8H17NO2
• Chemical IUPAC Name is 3-(aminomethyl)-5-methyl-hexanoic acid
• Molecular weight is 159.226 g/mol
• Lyrica available : 25mg capsules, 50mg capsules, 75mg capsules, 100mg capsules, 150mg capsules, 200mg capsules, 225mg capsules and 300mg capsules
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