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Livial, which is also called Tibofem, is a medicine that replaces hormones in the body. It copies the sex hormones of females, progesterone and estrogen, in the body to prevent and cure various conditions such as osteoporosis among postmenopausal women.

Women should always consult their doctors about taking Livial especially if they have certain conditions such as epilepsy, high level of bad cholesterol, liver diseases, migraines, obesity and personal and family history of clotting of the veins.

Taking of Livial is not advisable if women have incurred ailments in their blood vessels or around the brain, as well as history of cerebrovascular ailments, and cardiovascular diseases. Other conditions that may contradict with the use of Livial include thrombophlebitis, liver disease, hormone dependent cancer, and virginal bleeding. It is important that patients inform their doctors or pharmacists if they are allergic to any ingredients of Livial. Women who are pregnant or are planning to get pregnant should also inform their doctors about their condition or plan prior to taking the drug. The same goes for women who are breastfeeding their babies.

Patients should take Livial as indicated by their doctors. In case they do not fully understand the dosing instructions, they should never hesitate in asking a professional to explain the dosing indications. It is also critical that women who are planning to take this drug be briefed on the risks of the said drug, particularly since this can cause high probability or risks of breast cancer. It is also recommended that women taking Livial undergo regular gynecological consultations.

Dosage of Livial varies from person to person. Doctors prescribe the amount and the frequency of intake according to the conditions of the patient.

In case a patient misses a dose, immediately contact a pharmacist or doctor and ask for instructions. Never take 2 doses of Livial at the same time unless a specialist instructs you to.

For patients who suspect that they have overdose of the medicine, immediately contact their physicians and demand emergency medical help.

Like most drugs, Livial can pose some side effects to its users. Some of the more common side effects of this medication include depression, visual disturbances, abrupt changes in the results of liver function examinations, disturbances in the gut, abrupt change in weight, bleeding in the vagina, edema, pains in the muscles and joints, dizziness, headache, itching and rashes, development of facial hair, and seborrhoeic dermatitis.

Other more serious side effects of Livial include difficulty in breathing, abrupt chest pains, fainting, yellowing of the eyes or skin, serious condition of epilepsy, and pain while coughing or breathing.

Livial can also cause unwanted effects if taken with other medications. Some of the medicines that may affect the effectiveness of Livial are rifamycins such as rifampicin and rifabutin; antiepileptic medication such as phenytoin, primidone, Phenobarbital and carbamazepine; and barbiturates such as amobarbital. Consult with an expert first before taking any of these drugs. Some drugs apart from those listed may also have an effect while being taken with Livial.

Livial has the following structural formula:

Chemical structure of livial

• Molecular formula of livial is C21H28O2
• Chemical IUPAC Name is (7alfa,17beta)-17-ethynyl-17-hydroxy-7-methylestr-5(10)en-3-one
• Molecular weight is 312.446 g/mol
Livial available : 2,5mg tablets

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