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Apraclonidine is a medication commonly used in glaucoma therapy. This drug is commonly known as iopidine, though some are distributed as p-aminoclonidine and aplonidine. The medication is administered to patients when the current treatment is not enough to reduce eye pressure or to reduce eye pressure before and after surgery on the afflicted area.

Patients who want to reduce eye pressure or those who are planning to take laser eye surgery should use Apraclonidine. The medication is commonly used as a means to prevent the rise of pressure that occurs within the eye during this type of surgical procedure.

Prescription of apraclonidine includes 0.5% and 1% solution. The former is used as a substitute when the current medication of the patient is not doing any action in reducing the pressure in their eye.

The 1% solution is commonly used before and after the laser eye surgery; in most cases, one drop is administered before surgery and another drop afterwards. Doctors prescribe apraclonidine 0.5% for home use, while the 1% solution is released by the hospital before the procedure.

For glaucoma using apraclonidine 0.5%, medication is administered one drop in each eye for 2 to 3 times a day for adults. For apraclonidine 1%, one drop is administered in the afflicted eye before and after surgery to prevent ocular hypertension. Use of both medications on children requires a careful prescription from the doctor.

Common side effects to apraclonidine 0.5% and 1% involve an allergic reaction, which involves eye redness, itching, and tearing. But in rare cases, the patient will suffer from blurred vision, disorientation, dizziness, depression, irregular heartbeat, redness of the eyelid, swelling, and breathing troubles.

The above mentioned side effects may require the medical intervention, but there may be other reactions that are considered non-fatal; such as dryness of mouth, eye discomfort, and change in smell or taste; discoloration on the afflicted eye, runny nose, sore throat, sudden weaknesses, and sleeping troubles. These minor side effects disappear after treatment and require no further prescription from the doctor.

Patients receiving MAO inhibitors should not use apraclonidine. Anti-depressants are said to lower the effectiveness of the medication, like its hypotensive effect. It is quite possible that use of such drug might reduce the IOP lowering effect of apraclonidine. Also, an additive hypotensive effect was observed when patient use arpaclonidine with neuroleptic therapy.

Patients who are using both arpaclonidine 0.5% and 1% solution should have their vision monitored periodically. The medication might cause some patients to suffer from dizziness, drowsiness, and being less alert. Those who are suffering from these symptoms must refrain from doing activities that might cause accidents or fatal consequences. Using arpaclonidine might also make your eyes more sensitive to sunlight; it is advisable to stay indoors or wear sunglasses to avoid further irritation or discomfort.

Apraclonidine has the following structural formula:

Chemical structure of apraclonidine

• Molecular formula of apraclonidine is C9H10Cl2N4
• Chemical IUPAC Name is 2,6-dichloro-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine
• Molecular weight is 245.108 g/mol

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