Felbamate is a drug classified under the category of anti-epileptics or anticonvulsants.
The drug felbamate may be used alone as a monotherapy drug or in combination with other drugs in treating seizures for adult patients with epileptics.
Felbamate, marketed under the brand name Felbatol, is used for the treatment of severe seizures in adult epileptic patients. It is also used as a drug to treat Lennox-Gastaut syndrome in pediatric patients, which is also a form of epilepsy that causes behavioral and developmental problems in children.
Felbatol administration is done via the oral route and is available in tablets and oral suspension. Felbatol tablets come in 400-mg and 600-mg formulations and the oral suspension is formulated at 600 mg/5mL. The oral suspension is peach in color.
The usual recommended dosage for adult patients 14 years old and above begins with 1200 mg of Felbatol daily administered every 6 to 8 hours. For children 2 to 14 years of age, the dosage relies on the body weight, with an initial recommended dose of 15 to 45 mg per kilogram of body weight administered every 6 to 8 hours.
Allergic reactions may occur as side effects upon the usage of the drug Felbatol. Emergency medical attention is to be sought once any of the signs of allergies occur, such as fever, swollen glands, difficulty in breathing, swollen lips, face, mouth, and painful sores.
Less serious side effects reported include nausea, dizziness, headaches, insomnia, mild acne and skin rashes, metallic taste in the mouth, blurred vision, vomiting and constipation.
Felbatol may also cause side effects that affect the mental and psychological state of the patients. Mood or behavioral changes such as depression, restlessness, aggressiveness, anxiety and even suicidal tendencies are some of the mental side effects of the drug.
Felbatol is contraindicated in patients with a known hypersensitivity to the drug, its known components and with other anti-epileptic drugs. It is also not advised for use by patients with a known impairment in the liver and in the kidneys. For patients with kidney problems, special dosages may be given to adjust for the renal impairment.
A detailed medical history of the patient, including past and present conditions and medications, specially other anti-epileptic drugs such as divalproex, carbamazepine, phenobarbitals, phenyotins and valproic acid must be reported to the doctor as they may cause harmful adverse reactions with the administration of Felbatol.
Felbatol has been found out to decrease several types of blood cells (red, white blood cells and platelets); hence, caution must be exercised when administering the drug to patients with problems of the blood. Liver damage may also result from the use of the drug; as such, patients with liver impairments are cautioned prior to the use of the drug.
Apart from the physiological reactions the drug brings, it may also cause patients to have severe suicidal thoughts and intentions. It may also cause anxiety and depression.
It is not known if Felbatol harms the unborn baby. Pregnant women must consult their doctors prior to usage of the drug. Pregnant women must only use the drug if the benefits outweigh the risks involved. As other drugs may pass into breast milk, nursing mothers are advised not to take Felbatol when breast feeding, as it may cause harm to the nursing infant.
Felbamate has the following structural formula:
• Molecular formula of felbamate is C11H14N2O4
• Chemical IUPAC Name is (3-carbamoyloxy-2-phenyl-propyl) carbamate
• Molecular weight is 238.24 g/mol
• Felbamate available : 400mg tablets and 600mg tablets
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