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Abacavir

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Abacavir

Abacavir review





Abacavir sulfate is the generic name for a drug that also goes by the brand name Ziagen. It is given in tablets and in an oral solution.

ABACAVIR ACTION

It is an antiretroviral agent, called a nucleoside analog reverse transcriptase inhibitor, or NRTI, used to treat the human immunodeficiency virus, or HIV-1. It is also found in the combination formulas Trizivir and Kivexa/Epzicom, and is always used in combination with other antiretroviral agents.

Abacavir cannot cure or prevent HIV or AIDS, but it can help slow the reproduction of the HIV-1 virus, and that in turn helps keep the HIV from destroying the immune system. The longer the immune system can stay healthy, the longer secondary and opportunistic diseases and infections can be fought off, and the longer you can enjoy good health and quality of life. It is important to remember that Abacavir cannot keep HIV from spreading through sexual contact or contaminated blood, so the standard precautions in those matters should be taken.

ABACAVIR SIDE EFFECTS

Abacavir is generally well tolerated, but the most serious side effect is a rare hypersensitivity reaction that some people experience. This is a significant and sometimes even fatal reaction that is often displayed as fever, rash, nausea, vomiting, diarrhea, abdominal pain, fatigue or achiness, difficulty breathing, cough, or sore throat. There are other, less common signs of hypersensitivity, which include lethargy, liver or kidney failure, respiratory failure, conjunctivitis, numbness or tingling. If you are taking Abacavir and experience these effects, you should stop taking it immediately, even if you are not sure that you are having a hypersensitivity reaction. If your doctor rules out this reaction, you can then begin your treatment again. If you are having a hypersensitivity reaction, you must be careful never to take Abacavir sulfate or any medication that contains it, as it could be fatal for you.

Other side effects of Abacavir can include vivid dreams or other problems sleeping, headaches or migraines, increased risk of heart attack, nausea or vomiting, fatigue or lethargy, diarrhea, rashes, abdominal pain, depression, dizziness, muscle pain, fever and chills, ear, nose, or throat infections, anxiety, impaired kidney function, anemia, loss of appetite, pink-eye, bruises or white spots in the mouth, viral infections in your lungs, pneumonia, shortness of breath, blistering of skin, Stevens-Johnson syndrome, lactic acidosis, and generalized pain.

ABACAVIR DURING PREGNANCY

Abacavir is in Pregnancy Category C, which means that it is not known whether it will harm a developing fetus or complicate a pregnancy. Animal studies have shown that some negative effects can occur to fetuses at high dosages, but no conclusive studies have been done on human subjects. Therefore, Abacavir should only be taken during pregnancy if it is very clear that the benefits outweigh the risks. It is not known whether Abacavir is transmitted through breast milk, but it is strongly recommended that HIV-positive mothers not breastfeed their babies, since HIV can be transmitted to the child this way. Abacavir is safe for children from ages three months to sixteen years.

Abacavir has the following structural formula:

Chemical structure of abacavir


 Molecular formula of abacavir is C14H18N6O
 Chemical IUPAC Name is [4-(2-amino-6-cyclopropylamino-9H-purin-9-yl)-1-cyclopent-2-enyl]methanol
 Molecular weight is 286.333 g/mol
 Abacavir available: 20mg/ml solution, 300mg tablets

Brand name(s): Kivexa, Trizivir, Ziagen

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