Acenalin review

People with gastrointestinal problems can now find relief with the development of Acenalin. The effective actions of the medication have shown to be quite useful for many for years to come. It does have a number of reactions and effects that should be watched out for.

Acenalin is the generic name of the gastrointestinal stimulant medication used for the treatment of nighttime heartburn, bowel constipation and GERD or gastroesophageal reflux disease. It is also known under its brand name Propulsid and Prepulsid. Patients who do not respond well to other forms of treatment and therapies are given Acenalin to improve their condition.

Acenalin comes in liquid form and pills that should be taken orally. Although the medication has shown potency in treating bowel disorders, doctors are discouraged from immediately giving the medication unless other alternatives are rendered ineffective. It was approved by the FDA or Food and Drug Administration in 1993 but later was withdrawn in several areas or had limited indications due to reports of arrhythmia and cardiac irregularities.

The gastrointestinal stimulant medication is also indicated in treating megaesophagus and feline megacolon. However, it should not be used for other alternative uses unknown to doctors. It is also useful for nausea stemming from motility problems. Acenalin is highly related to metoclopramide for their similar effects but the latter is more potent in treating neurological reactions.

A number of side effects can also result from the medication, which should be cautiously watched out for. Patients should stop the medication immediately and report to their doctor if any of these are noticed: fainting, allergic reactions, cardiac arrhythmia, chest pain, difficulty breathing and vision changes. Less serious side effects include abdominal pain, diarrhea, constipation, nausea, urinary frequency, upset stomach, rhinorrhea, cough and headache. Patients may resume taking Acenalin but the symptoms should still be reported. Acenalin overdose is also possible and diagnosed through manifestations like diarrhea, vomiting, flatulence, tremor, seizure, weakness and nausea.

Pregnant women and nursing mothers should consult their doctor before taking the medication. Patients trying to become pregnant should not take the medication since it can reduce fertility. Acenalin may also interact with medicaments like cimetidine, ranitidine, antifungals like ketoconazole, antihistamines, psychoactive medicaments, heart medicaments and benzodiazepines. If there is actual intestinal perforation or obstruction, the medication is contraindicated. Pomegranate juice, tobacco, alcohol, grapefruit juice and red wine are also known to reduce the effects and absorption of the medication in the body. Other contraindications include patients with a history of heart and arterial disease.

Acenalin is a parasympathomimetic medication that acts as an agonist for serotonin 5-HT4 receptors. Once the receptors are stimulated, acetylcholine levels will rise in the enteric nervous system thereby improving the gastroesophageal condition. The esophageal sphincter also improves with effective gastric emptying.

A clinical trial involving 18 patients suffering from GERD were treated with Acenalin and metoclopramide. The group was divided into two wherein the first batch was given Acenalin while the second took metoclopramide. After 7 days, both batches exhibited improvement in gastroesophageal condition. The first batch did experience nausea for 1 to 2 days but the second batch reported experiencing moderate neurological side effects.

Acenalin is a prescription medication and should only be bought from authorized clinics and pharmacies. Be sure to verify any online pharmacy before purchasing to guarantee authenticity of products.

Acenalin can be given up to three times daily. Never take more than the recommended dosage. The medication should be stored at room temperature free from heat, moisture and children's reach. Watch out for symptoms of overdose and immediately call for help if anything results. Doctors require laboratory assessment to ensure the safety of the patient with the medication.

Acenalin has the following structural formula:

Chemical structure of acenalin

• Molecular formula of acenalin is C23H29ClFN3O4
• Chemical IUPAC Name is 4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl]-2-methoxybenzamide
• Molecular weight is 465.9455 g/mol
Acenalin available : 5mg tablets, 10mg tablets

Generic name: Cisapride

Brand name(s): Alimix, Cipril, Enteropride, Kinestase, Prepulsid, Pridesia, Propulsid, Propulsin, Risamal, Syspride

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