Aceplus review

Aceplus is an angiotensin-converting enzyme inhibitor that is used for the treatment of hypertension (high blood pressure) and cases of congestive heart failure. It keeps angiotensin, a chemical in the blood, from metabolizing into a dangerous substance that allows the body to retain more salt and water, leading to hypertension and eventual heart failure.

Aceplus also works by relaxing the blood vessels and enabling blood to flow more freely throughout the body. It can be used alone or taken with diuretics in the treatment of high blood pressure. For management of congestive heart failure, it is usually combined with both digitalis and diuretics.

This medicament is also used to treat kidney disorders in diabetic patients. It reduces the risk of further cardiopulmonary arrest in patients who have previously had a heart attack, and can improve the chances of survival after heart failure.

Aceplus has been prescribed for the treatment of angina pectoris (a crushing chest pain), rheumatoid arthritis, and Raynaud's phenomenon (a blood vessel disorder).

Patients allergic to Aceplus or any of its ingredients, women who are in the second or third trimester of their pregnancy (Aceplus can cause fetal death), people who have a history of allergies to ACE inhibitors, and those who are taking dextran sulfate should not take Aceplus.

Before taking Aceplus, patients should tell their doctor if they have any medical conditions including food, medicine or substance-related allergies, a history of bone marrow depression, high blood potassium levels or low blood sodium levels, a history of kidney disease, or if they are currently undergoing dialysis or have had a previous kidney transplant, a history of heart disease, the autoimmune disease, lupus, a sodium-restricted diet, or if they are breastfeeding.

Aceplus may affect the results of some laboratory tests such as urine ketone tests of diabetes patients. As Aceplus may cause adverse reactions when taken with certain medicaments, patients need to inform their doctor of all the medicaments, including vitamin, mineral and herbal supplements they may be taking.

Some of the medicaments that interact with Aceplus include dextran sulfate (Allopurinol), which can cause allergic reactions; diurectics, which increases the risk of low blood pressure and low blood sodium; NSAIDs (nonsteroidal anti-inflammatory medicaments), which can lower the effectiveness of Aceplus; Lithium or thiopurines; oral diabetes medicaments, which may lower blood sugar levels, and Potassium supplements, which may further increase blood potassium levels.

Aceplus may also cause adverse reactions like coughing, a rash, and a metallic taste in the mouth. In some cases, patients on Aceplus may experience hypotension, a condition where blood pressure becomes abnormally low, and hyperkalemia, which is indicated by excessive potassium in the blood.

Other side effects include dizziness or lightheadedness, which may be aggravated by alcohol consumption; fainting; fatigue; diarrhea; vomiting; headaches; pruritus and fever. If the patient experiences severe allergic reactions like hives, pruritus, breathing difficulties, swelling of the facial tissues, jaundice, irregular heartbeat, fainting and signs of infection like fever and sore throat, they should discontinue use of Aceplus and seek emergency medical attention immediately.

Aceplus is distributed by Bristol-Myers Squibb under the brand names Capoten or Inhibace. It also comes under another brand, Capozide. Depending on the patient's condition and doctor's prescription, Aceplus should be taken orally on an empty stomach, an hour before meals. For high blood pressure, diabetes-related kidney ailments, and for patients recovering from heart failure, the usual dosage is 25 mg., 2 to 3 times a day. Patients who have just suffered a heart attack are usually give an initial 6.25 mg. dose once, followed by 12.5 mg. 3 times a day. Aceplus use should not exceed 450 mg. daily to prevent an overdose.

Aceplus has the following structural formula:

Chemical structure of aceplus

• Molecular formula of aceplus is C9H15NO3S
• Chemical IUPAC Name is (2S)-1-[(2S)-2-methyl-3-sulfanyl-propanoyl]pyrrolidine-2-carboxylic acid
• Molecular weight is 217.286 g/mol
Aceplus available : 12.5mg tablets, 25mg tablets, 50mg tablets, 100mg tablets

Generic name: Captopril

Brand name(s): Acediur, Acepress, Acepril, Alopresin, Apopril, Capoten, Capozide, Captolane, Captoprilum, Captopryl, Captoril, Cesplon, Dilabar, Garranil, Hipertil, Hypertil, L-Captopril, Lopirin, Lopril, Tenosbon, Tensobon, Tensoprel

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