Acepril review

Acepril, an angiotensin-converting enzyme inhibitor, is used for the treatment of hypertension (high blood pressure) and cases of congestive heart failure. It keeps a chemical in the blood, angiotensin, from metabolizing into a dangerous substance that allows the body to retain more salt and water, leading to hypertension and eventual heart failure.

Additionally, Acepril works by relaxing the blood vessels and enabling blood to flow more freely throughout the body. It can be used on its own or taken with diuretics in the treatment of high blood pressure. For management of congestive heart failure, it is typically combined with both digitalis and diuretics.

This medication can also be used to treat kidney disorders in diabetic patients. It reduces the risk of further circulatory arrest in patients that have previously had a myocardial infarction, and can improve the chances of survival after heart failure.

Acepril can be used for the treatment of angina pectoris (a crushing chest pain), rheumatoid arthritis, and Raynaud's phenomenon (a blood vessel disorder).

Patients allergic to Acepril or any of its ingredients, women in the second or third trimester of their pregnancy (Acepril can cause fetal death), patients with a history of allergies to ACE inhibitors, and those who are taking dextran sulfate should not take Acepril.

Before taking Acepril, patients should tell their doctor if they have any medical conditions including food, medicine or substance-related allergies, a history of bone marrow depression, high blood potassium levels or low blood sodium levels, a history of kidney disease, or if they are currently undergoing dialysis or have had a previous kidney transplant, a history of heart disease, the autoimmune disease, lupus, a sodium-restricted diet, or if they are breastfeeding.

Acepril can affect the results of some laboratory tests such as urine ketone tests of diabetes patients. As Acepril may cause adverse reactions when taken with certain medications, patients need to inform their doctor of all the medications, including vitamin, mineral and herbal supplements they may be taking.

Some of the medications that interact with Acepril include dextran sulfate (Allopurinol), which cause allergic reactions; diurectics, which increases the risk of low blood pressure and low blood sodium; NSAIDs (nonsteroidal anti-inflammatory medications), which can lower the effectiveness of Acepril; Lithium or thiopurines; oral diabetes medications, which may lower blood sugar levels, and Potassium supplements, which may further increase blood potassium levels.

Acepril may cause adverse reactions like coughing, a rash, and a metallic taste in the mouth. Some patients on Acepril may experience hypotension, a condition where blood pressure becomes abnormally low, and hyperkalemia, which is indicated by excessive potassium in the blood.

Other known side effects include dizziness or lightheadedness, which may be aggravated by alcohol consumption; fainting; fatigue; diarrhea; vomiting; headaches; itching and fever. If the patient experiences severe allergic reactions including hives, itching, breathing difficulties, swelling of the facial tissues, jaundice, irregular heartbeat, fainting and signs of infection like fever and sore throat, they should discontinue use of Acepril and seek emergency medical attention immediately.

Acepril is distributed by Bristol-Myers Squibb under the brand names Capoten or Inhibace. It also is available under another brand, Capozide. Depending on the patient's condition and the prescription, Acepril should be taken orally on an empty stomach an hour before meals. For high blood pressure, diabetes-related kidney ailments, and for patients recovering from heart failure, the usual dosage is 25 mg., 2 to 3 times a day. Patients having just suffered a myocardial infarction are usually give an initial 6.25 mg. dosage once, followed by 12.5 mg. 3 times a day. Acepril dosages should not exceed 450 mg. daily to prevent an overdosage.

Acepril has the following structural formula:

Chemical structure of acepril

• Molecular formula of acepril is C9H15NO3S
• Chemical IUPAC Name is (2S)-1-[(2S)-2-methyl-3-sulfanyl-propanoyl]pyrrolidine-2-carboxylic acid
• Molecular weight is 217.286 g/mol
Acepril available : 12.5mg tablets, 25mg tablets, 50mg tablets, 100mg tablets

Generic name: Captopril

Brand name(s): Acediur, Aceplus, Acepress, Alopresin, Apopril, Capoten, Capozide, Captolane, Captoprilum, Captopryl, Captoril, Cesplon, Dilabar, Garranil, Hipertil, Hypertil, L-Captopril, Lopirin, Lopril, Tenosbon, Tensobon, Tensoprel

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