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Acibilin

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Acibilin

Acibilin review





Acibilin is a medication used to prevent ulcers in the stomach and small intestines, gastroesophageal reflux illness, upper GI bleeding and acid reflux. There are also unlabeled uses that include: the prevention of aspiration of pneumonia and stress ulcers, and herpes virus infection and can be used prior to anesthesia to prevent aspiration pneumonitis.

Acibilin works by blocking histamine, which is responsible for releasing acid in the stomach. Tagamet is the brand name for this medication and it can be dispensed in tablet or liquid form. Acibilin is taken orally with or without food. It is not recommended to ingest an antacid one hour before or after taking this medication. Cephalosporin, itraconazole and ketoconazole should be taken two hours prior to taking Acibilin. If a dosage is missed, take the dosage as soon as remembered, but do not take more medication to make up for missed dosages and do not take more than one dosage at a time.

Acibilin has been classified, by the FDA, as pregnancy category B and it has been proven that this medication can be excreted in breast milk. It is imperative the prescribing physician be notified if the patient is pregnant or plans to become pregnant. The physician should also be notified if the patient is allegeric to any ingredients of Acibilin. Extreme caution should be used when prescribing to the elderly, as they may have reduced renal function, and to children under 16, as the medication has not been established for safety and efficacy.

There are several medication and dietary interactions that can occur while taking this medication. A patient cannot take Acibilin if they are taking medicine for cancer, asthma, high blood pressure, erectile dysfunction or if they are taking cisapride, dofetilide or nitrosoureas. Any antacids, anticholinergics, or metoclopramide may inhibit the body from completely adsorbing the Acibilin. Acibilin may reduce the effectiveness of the following medications: tricyclic antidepressants, calcium channel blockers, quinine and caffeine. If taken with carmustine there is the possibility that bone marrow toxicity will be enhanced. This medication will not interfere with any lab testing. Patients should be advised not to take over-the-counter medications, herbal medicines or dietary supplements without the prescribing physician's knowledge. Some counseling regarding lifestyle changes, stress reduction and dietary changes (no spicy foods and alcohol) is recommended. Laboratory testing and follow-up visits will be important to monitor the efficacy of the medication. Smoking cessation is highly recommended due to the fact that smoking will reduce the ulcer healing efficacy of Acibilin.

There are several side effects that may occur while taking this medication. Dizziness and drowsiness can occur and patients should not drive or perform highly complicated tasks until they know how they will be affected while on this medication. If there is any black tarry stool, abdominal pain, confusion or coffee-ground emesis, the physician should be notified immediately. Severe side effect can include: breast enlargement or lumps, anxiety, agitation, diarrhoea, bronchospasm, fatigue, hallucinations, hair loss, joint or muscle pain, loss of libido or cardiac arrhythmias. If an overdosage of the medication is suspected, the patient should be immediately taken to the emergency room or contact a local poison control center. An overdosage may present with a variety of symptoms including but not limited to nausea, vomiting with coffee ground substance, hallucinations, diarrhoea, and severe anxiety or emotional disturbance.

Acibilin has the following structural formula:

Chemical structure of acibilin


• Molecular formula of acibilin is C10H16N6S
• Chemical IUPAC Name is 1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine
• Molecular weight is 252.34 g/mol
Acibilin available : 300mg tablets, 400mg tablets

Generic name: Cimetidine

Brand name(s): Acinil, Carbamazapine, Cimal, Cimetag, Cimetum, Dyspamet, Edalene, Eureceptor, Gastromet, Peptol, Tagamet, Tametin, Tratul, Ulcedin, Ulcedine, Ulcerfen, Ulcimet, Ulcofalk, Ulcomedina, Ulcomet, Ulhys

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