, generically known as ampicillin
, is an extensively used beta-lactam antibiotic used to remedy bacterial infections
since 1961. It is believed to be part of the aminopenicillin group and is approximately equal to amoxicillin
in terms of range and level of effectiveness. As a member of the beta-lactam penicillin
group of antibiotics, Acillin is capable of penetrating both gram-negative and gram-positive bacteria, although there are some Gram-negative bacteria that it could not affect.
The only difference between Acillin and penicillin is the presence of an amino group in the ampicillin-based medication. That amino group assists Acillin in piercing through the outer membrane of a number of gram-negative bacteria. It also serves as a competitive inhibitor of the enzyme transpeptidase, which is required by bacteria to synthesize their cell walls. The drug restrains the third and final stage of bacteria cell wall creation, which eventually leads to cell lysis.
250 to 500 milligrams four times every day for one to two weeks is the recommended oral dose range of Acillin for most infections. As for gonorrhea treatment
, a solitary 3.5 gram dose—that is, seven 500 milligram capsules—should be taken with Benemid (probenecid). Benemid inhibits the elimination of Acillin in the body, so it remains in your system for a while longer than normal.
Remember to take each dose with a full glass of water and an empty stomach
one hour before or two hours after meals. The medicine should also be administered at evenly spaced intervals throughout the day and night in order to keep the amount of ampicillin in your blood
at optimum levels, which will in turn help greatly in speeding up the treatment of your bacterial infection.
As noted earlier, Benemid (probenecid) can cause an increase in the amount of ampicillin in the body, so you must consult your doctor in regards to Benemid intake during Acillin treatment. On the other hand
, using Acillin with Zyloprim
(allopuinol) can increase your chances of developing a drug-related skin rash. Patients should also take note that a high percentage of patients with infectious mononucleosis have developed rash during Acillin treatment, and a low incidence of cross-allergy with other beta-lactams have been reported to occur. Appearance of a rash should be carefully examined to distinguish between hypersensitivity reaction and a non-allergic ampicillin-caused rash.
Acillin can occasionally cause non-allergic reactions that range in seriousness from rash—for instance, patients with mononucleosis—to potentially life-threatening anaphylaxis
. Consult your pharmacist or physician for more information. In any case, once your doctor deems Acillin as a safe drug for you to use, you must take all of the Acillin prescribed to you even if you've begun to feel better. That's because your symptoms may start to improve before the infection is fully treated. Adjusting your dosage may be required in patients with renal impairment as well.
Even though Acillin is considered safe to use during pregnancy, it also passes in breast
milk and may cause allergic responses or diarrhea
in nursing infants. If this medication is to be used during pregnancy, the potential benefit of Acillin for the mother should be weighed against the potential risk of side effects in the unborn child. Consult your doctor or pharmacist for further evaluation.
In regards to storage, tablets and capsules must be kept at room temperature while the suspension must be put inside the refrigerator for extended use. The suspension is good for a week at room temperature and for two weeks if stored inside the refrigerator. Discard any unused Acillin suspension after its expiry date because its effectiveness would have been reduced by then.
Common Acillin side effects include dizziness
, rash, abdominal pain, diarrhea, loss of appetite
, and nausea
. Patients who are normally allergic to penicillin-based medications should not take Acillin. People with allergies
to cephalosporin class of antibiotics that are related to penicillin drugs—Cefzil, Keflex
, and so on—may or may not be allergic to Acillin.
Serious but rare Acillin side effects include low platelet or red blood cell count, severe allergic reactions
or anaphylaxis, and seizures. Acillin can also change the normal bacteria in the colon
and cause overgrowth of some bacteria such as Clostridium difficile, which causes inflammation of the colon or pseudomembranous colitis. Symptoms of pseudomembranous colitis include possible shock, abdominal pain, fever
, and diarrhea. Contact your doctor for further details.
Acillin has the following structural formula:
• Molecular formula of acillin is C16H19N3O4S
• Chemical IUPAC Name is 7-(2-amino-2-phenyl-acetyl)amino-3,3-dimethyl-6-oxo- 2-thia-5-azabicyclo[3.2.0]heptane-4-carboxylic acid
• Molecular weight is 349.406 g/mol
• Acillin available : 250mg capsules, 250mg capsules, 500mg capsules
Generic name: Ampicillin
Brand name(s): Adobacillin, Alpen, Amblosin, Amcill, Amfipen, Amfipen V, Aminobenzylpenicillin, Amipenix S, Ampen, Ampi, Ampi-Bol, Ampi-Co, Ampi-Tab, Ampichel, Ampicil, Ampicilina, Ampicillina, Ampicilline, Ampicillinum, Ampicin, Ampifarm, Ampikel, Ampimed, Ampipenin, Ampiscel, Ampisyn, Ampivax, Ampivet, Amplacilina, Amplin, Amplipenyl, Amplisom, Amplital, Ampy-Penyl, Austrapen, Binotal, Bonapicillin, Britacil, Campicillin, Cimex, Copharcilin, Delcillin, Deripen, Divercillin, Doktacillin, Duphacillin, Geocillin, Grampenil, Guicitrina, Guicitrine, Lifeampil, Morepen, Norobrittin, Novo-Ampicillin, Nuvapen, Olin Kid, Omnipen, Omnipen-N, Orbicilina, Pen Ampil, Penbristol, Penbritin, Penbritin-S, Penbrock, Penicline, Penimic, Pensyn, Pentrex, Pentrexl, Pentrexyl, Polycillin, Ponecil, Princillin, Principen, Qidamp, Racenacillin, Ro-Ampen, Rosampline, Roscillin, Semicillin, Servicillin, Spectrobid, Sumipanto, Supen, Synpenin, Texcillin, Tokiocillin, Tolomol, Totacillin, Totalciclina, Totapen, Trifacilina, Ultrabion, Ultrabron, Vampen, Viccillin, Wypicil