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Activase

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Activase

Activase review





Activase is a medication used to treat all types of blood-clot-related conditions. It is comparable to a naturally occurring enzyme found in humans that causes blood clots to dissolve and dissipate. The medication, Activase, is a manmade protein manufactured using recombinant Deoxyribonucleic acid technology.

The amount of Activase given to patients suffering from blood clots is considerably more than the amount naturally produced by the body. First approved for myocardial infarctions in 1987, Activase was eventually approved for stroke treatment in 1996.

Activase, also known as Alteplase, is an injectable medication administered directly into a vein to treat people with conditions caused by arterial blood clots, including pulmonary thrombosis (blood clots in the lungs), unstable angina (chest pain at rest), strokes, myocardial infarctions, and other less common diseasees involving blood clots.

The advised daily dosage for Activase is based on the patient's weight and limited to a maximum amount of 100 milligrams. It is injected intravenously. Depending on the severity of the patient's condition, the drug is either administered once quickly or as a brief infusion for a period of half an hour to an hour.

You can also mix the drug's powder with sterile water for injection at concentrations of 50 milligrams per 50 milliliters to 100 milligrams per 100 milliliters. The vials should be stored at room temperature up to 30C (80F) or inside a freezer at 2-8 C (36-46 F). Once it is mixed with sterile water, the drug must be used without delay. All unused solutions should be discarded immediately.

Bleeding is the most common and serious side effect of Activase. Most bleeding is fortunately minor, but it is also significant, and fatal bleeding does occur. Other typical side effects include mild pyrexia, dizziness, vomiting, and nausea. If any of these symptoms persist or become worse, promptly seek medical attention.

You should also consult your doctor immediately if you experience chest pain, rapid or abnormal heartbeat, breathing difficulties, skin rash, easy bruising, or easy bleeding. You should also notify your doctor, as soon as possible, if you develop any signs or symptoms of bleeding. Even if you experience other symptoms not listed above, contact your pharmacist or doctor and describe your symptoms.

Before undergoing Activase treatment, inform your doctor of your medical history, especially if you have the following conditions: allergies of any kind, endocarditis, liver disease, recent injury or surgery, high blood pressure, or other bleeding disorders. You should also practice extra caution in order to avoid trauma or injury while using this medication because of the added risk of bleeding.

If you are pregnant, this medication should only be used when clearly needed. Consult your doctor in regards to the pros and cons of using this medicine while pregnant. You should also discuss with them whether or not you should breastfeed while undergoing Activase therapy.

Remember that Activase's ability to break down clots can interfere with your body's natural ability to stop bleeding. As such, any medication that also interferes with blood clotting or the clot-inducing abilities of platelets can increase your chances of bleeding to death.

Indeed, it would be best for you to avoid non-steroidal antiinflammatory drugss (nonsteroidal anti-inflammatory drugs) like Relafen (nabumetone), Naprosyn (naproxen), and Motrin (ibuprofen) or medications like Coumadin (warfarin) and aspirin. Then again, specific platelet inhibitors like Plavix (clopidogrel) don't appear to interact negatively with Activase or increase your risk of bleeding. As always, consult your doctor or pharmacist for more details.

• Molecular formula of activase is C2569H3928N746O781S40
• Molecular weight is 59042.3 g/mol

Generic name: Alteplase

Brand name(s): Reteplase

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