Adapin review

Adapin is a psychotropic drug used for patients with psychological disorders, more specifically those who have been diagnosed with depression and slight tendencies of suicidal tendencies. It is a water-soluble compound orally ingestible composed of a main dibenzoxepin tricyclic compound. Upon ingestion, some of its inactive ingredients are activated to produce the desired effect of antidepressants and anxiolytics. These inactive ingredients are glycerin, partial artificial flavoring, methylparaben, and propylparaben.

The main action potential of ingested Adapin targets the adrenergic activity of the body instead of the usually conceived monoamine oxidase inhibitors, or otherwise known as MAO inhibitors. In this regard, the Adapin drug deactivates the norepinephrine reuptake into the terminals or synapses.

A very potent and dangerous drug if given in wrong dosages and unknown conditions, Adapin should only be given under strict medication regimen and full knowledge of the patient's medical history, as well as current state of medication and status.

The drug is intended for the treatment of patients with psychoneurosis, or those who are in constant severe depression and anxiety, alcoholics and those who are having a massive traumatic emphasis during withdrawal, and manic-depressive disorders.

Those who have solid-state symptoms of anxiety, depression, somatic concerns, sleep disturbance, overly feelings of guilt, fatigue, fear, and apprehension are expected to be alleviated of these with proper and effective medication by the said drug. It is not recommended to be administered to children below 12 years of age as there are milder forms of therapeutic methods available to curb any of these symptoms.

The usual dosage for this drug is an initial per orem or PO medication of 75 milligrams a day, and to be increased to 300 milligrams per day, depending on the severity of the psychological attack on the patient.

Administration of drug is upon the discrepancy of the physician, but common practice is to give it during bedtime or in three divided doses throughout the day. As it has been studied that more than 300-milligram doses are not any more effective than the limit, such practices are considered beyond allowed norms and are highly discouraged.

Preparations of the drug available are in 10, 25, 50, 75, 100, and 150-milligram capsules, though there are some liquid preparations in 10 milligram per milliliter packages.

One of the most anticipated side effects after taking this drug is to see drowsiness. However, this side effect gradually improves and disperses as effective therapy continues, usually within 2 to 3 weeks. Other side effects are blurred vision and urinary retention. There have been reports and clinical findings that the drug may also cause dry mouth, constipation, weight gain, and bradycardia. Orthostatic hypotension, or the sudden decrease in the blood pressure from a lying to sitting position is also evident in several occasions.

There are also very rare side effects such as seizures, tachycardia, rashes, and hives reported for some individuals and are accounted to happen upon a missed dose or sudden withdrawal of the medication. It is therefore recommended that halting of the medication should be done gradually.

It is highly reactive and contraindicated for patients who are taking other drugs, especially MAO inhibitors as it may cause a series of adverse effects such as grave fluctuations in the blood pressure that may be fatal.

It is also contraindicated with other antidepressants such as barbiturates, narcotics, and anticonvulsive drugs as this may result in an increase in depression.

Other drug worth noting for contraindication of medication with dexepin are anticholinergics, cimetidine, sympathomimetics, nitrates, and clonidine. Combined medication would merit some of the following effects: hypertension, possible arrest, increased depression, increased anticholinergic actions, and rebound effects.

Adapin has the following structural formula:

Chemical structure of adapin

• Molecular formula of adapin is C19H21NO
Adapin available : 50mg tablets, 100mg tablets

Generic name: Doxepin

Brand name(s): Aponal, Curatin, Doxepina, Doxepine, Doxepinum, Novo-Doxepin, Quitaxon, Sinequan, Triadapin, Zonalon

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