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Agenerase

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Agenerase

Agenerase review





Agenerase was developed by GlaxoSmithKline and was first approved by the U.S. Food and Drug Association (FDA) in 1999 to be used in treating HIV infections. This was considered impossible with previous medical technology.

Agenerase is defined as a protease inhibitor. It is an antiretroviral medicament or Antiretroviral used in treating people with HIV. Studies show that people with HIV over 4 years of age can be given this medicament. Agenerase is commonly used for people who have a high viral load with low levels of cluster of differentiation 4 Cell Counts. This is used to keep HIV patients healthy with every treatment.

The Agenerase capsule is taken orally with a full glass of water. Adults are usually prescribed 1,200mg twice a day. This was first tested using the 150mg capsules that are no longer manufactured today. Considering that the Agenerase capsule is no longer manufactured; patients with HIV can take fosamprevanir as a substitute.

Today, Agenerase is approved for use along with ritonavir -- another protease inhibitor medicament. Dosage may include one of the following depending upon the advice of your doctor or physician:


1. 100mg of ritonavir along with 600mg or 4 capsules of Agenerase; twice a day; or
2. 200mg of ritonavir (2 caps) along with 1,200mg (8 caps) of Agenerase; once a day.

Common side effects associated with Agenerase include diarrhoea, nausea, vomiting, numbness around the mouth, rashes, and stomach pains. A small population of the patients taking Agenerase suffers from serious skin reactions, such as the Stevens-Johnson syndrome or other allergic reactions to the medicament. Doctors prescribe over-the-counter medicaments to control some of these side effects. If you develop any of these symptoms or other symptoms, consult your doctor immediately.

People with an allergic reaction to sulfa medicaments might want to refrain from using Agenerase or seek the advice of a doctor if you plan to proceed with the treatment. Considering that Agenerase is a protease inhibitor, there are no records of problems occurring for people suffering from high-cholesterol levels unlike other medicaments in the same family.

Liquid-based Agenerase contains glycol that may cause some problems for infants under 4 years old, people suffering from kidney or liver problems, pregnant women, or those taking specific medicaments.

There is a possibility that Agenerase will react with other medicaments or herbal supplements. Both medicaments in the system might trigger an overdose that could prove fatal to the patient or an underdose that will render the treatment useless.

In most cases, other Antiretroviral medicaments are said to interact adversely with Agenerase. Patients currently treated with tuberculosis medicaments should avoid using this medicament. Medications to treat headaches and migraines, as well as those used for erectile dysfunctions and to control heart rhythms should be avoided when being treated with Agenerase or vice versa.

As with other protease inhibitors, patients who are planning a treatment using Agenerase must consult their doctor for a thorough physical and medical examination to avoid risks, as well as following the prescribed dose to avoid contraindications and fatal reactions.

Agenerase has the following structural formula:

Chemical structure of agenerase


• Molecular formula of agenerase is C25H35N3O6S
• Chemical IUPAC Name is tetrahydrofuran-3-yl[3-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-1-benzyl-2-hydroxy-propyl]aminomethanoate
• Molecular weight is 505.628 g/mol
Agenerase available : 50mg capsules

Generic name: Amprenavir

Brand name(s): Lexiva

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