Aggrenox review

Aggrenox is a medication that lessens the risks of stroke among patients who have suffered from transient ischemic stroke resulting from thrombosis. Aggrenox combines aspirin and dipyridamole in preventing stroke, which occurs when blood clot impedes smashed blood vessels that lead to or in the brain. Blood clots are usually formed by platelets that clump together in plugging holes in damaged blood vessels.

Aspirin is effective in the reduction of the growth of prostaglandins, or natural substances that enable platelets to stick together and develop blood clots. Dipyridamole, on the other hand, prevents clots from further forming.

Both aspirin and dipyridamole cannot stand alone as a replacement for aggrenox. When both of these substances are combined in aggrenox, they make an effective combination medication that can prevent clots from developing and resulting to stroke.

Aggrenox must be taken by patients twice a day- once in the morning and another dosage in the evening. Aggrenox can be swallowed, and can be taken without or with food.

If a patient misses a dose of Aggrenox, he or she must take it immediately. But if it is time for the next dose, the patient must take the next dose and not take 2 doses at one time. Aggrenox must be kept at room temperature to protect the tablets from excessive moisture.

It should not be taken by individuals who have a history of allergy to aspirin as well as other anti-inflammatory medications like naproxen and ibuprofen. It should also not be taken by those who are prone to asthma attacks after using aspirin.

The effects of Aggrenox may increase or altered if the user takes other drugs. Patients must check with their doctors if it is safe to take Aggrenox especially if they are taking ACE inhibitors or medication for heart pressure like captopril; methotrexate, acetazolamide, blood-thinning medications like warfarin sodium; and gout medications. Other medications such as oral drugs for diabetes like valproic acid and water pills like furosemide may also have an effect on Aggrenox.

Those who are suffering from muscle ailment called myasthenia gravia may likewise be at risk of having their drug therapy interfere with Aggrenox.

Aggrenox is also not recommended for pregnant women. The medication may harm a baby, resulting to the infant having low weight, bleeding inside the brain, and at times, death. Pregnant women who are into their last 3 months should not use aggrenox.

Women who use aggrenox should notify their doctors immediately if they become pregnant or are planning to be pregnant. Aggrenox may also cause a brain disorder known as Reye’s Syndrome among children suffering from viral illness.

Aggrenox can have side effects, although the chances are quite remote. It should be noted that side effects of aggrenox is hard to anticipate. In case a patient discovers worsening case of side effects, it is advised that he or she immediately informs a physician.

Some of the more common side effects of aggrenox include back pain, abdominal pain, bleeding, dizziness, diarrhea, headache, fatigue, indigestion, pain, nausea, joint pain, and vomiting.

Aggrenox has the following structural formula:

Chemical structure of aggrenox

• Molecular formula of aggrenox is C24H40N8O4
• Chemical IUPAC Name is 2-[[3-[bis(2-hydroxyethyl)amino]-5,10-bis(1-piperidyl)-2,4,7,9-tetrazabicyclo[4.4.0]deca-2,4,7, 9,11-pentaen-8-yl]-(2-hydroxyethyl)amino]ethanol
• Molecular weight is 504.626 g/mol
Aggrenox available : 25mg tablets, 50mg tablets, 75mg tablets

Generic name: Dipyridamole

Brand name(s): Agilease, Anginal, Apricor, Cardioflux, Cardoxil, Cardoxin, Chilcolan, Cleridium, Coribon, Coridil, Coronarine, Corosan, Coroxin, Curantyl, Dipiridamol, Dipyridamine, Dipyridamol, Dipyridan, Dipyudamine, Dypyridamol, Gulliostin, Justpertin, Kurantil, Natyl, Novo-Dipiradol, Peridamol, Permiltin, Persantin, Persantine, Piroan, Prandiol, Protangix, Stenocardil, Stenocardiol, Stimolcardio

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