Alprostadil review

Alprostadil, also known as Prostaglandin E1, is used to manage erectile dysfunction through its vasodilatory features. It is sold in the United States under the brand name Muse or Medicated Urethral Suppository for Erection by Vivus. It is also available as Caverject and Edex, which are brand names for its injectable form. Muse transports the drug as a penile drug delivery system inserted into the urethra for at least ten minutes before you need an erection. In contrast, the likewise fast-acting Caverject and Edex are injected directly into the penis's corpus cavernosum.

This drug is recommended for people with erectile dysfunction problems. You can also use this medication to preserve a patent ductus arteriosus in the newborn. This is mostly effective when there is a danger of premature ductus arteriosus closure in a baby with ductal-dependent congenital heart disease including acyanotic lesions (that is, interrupted aortic arch, critical aortic stenosis, hypoplastic left heart syndrome, and coarctation of the aorta).

This drug may be taken as needed to achieve penile erection. The effect starts about five to ten minutes after administration and can last from about thirty minutes to a whole hour. Dosage should be ascertained by your doctor, and you will be examined for any unfavorable side effects afterwards. Follow the approved instructions precisely. You should be instructed in detail on usage by a healthcare specialist before trying to administer the drug by yourself. Remember that each product is for single use only and should not be used repeatedly.

Common side effects of alprostadil include headache, flu symptoms, palpitations, dizziness, minor penile bleeding or spotting, and penile/testicular pain. If any of these adverse effects persist or worsen, consult your doctor promptly. You should also report the very rare but grave side effects of severe unsteadiness or fainting due to possible blood pressure decrease.

As for the side effects on your female partner, she may sometimes experience vaginal burning or itching after sex. It is currently unclear if that has anything to do with the drug itself or not. If you notice any other side effects not listed in this article, feel free to immediately contact your pharmacist or doctor in regards to that.

Before taking this drug, inform your doctor of all the prescription and nonprescription medications you've been taking, especially medicines that can sometimes cause erection problems like MAO inhibitors (furazolidone, selegiline, phenelzine), blood thinners (aspirin, warfarin, NSAIDs), phenothiazines (chlorpromazine), anti-anxiety drugs, calcium channel blockers or other high blood pressure medications, hydralazine, terazosin, prazosin, propranolol (beta-blockers), guanfacine, guanabenz, disopyramide, clonidine, thiazide water pills, methyldopa, spironolactone, and tricyclic antidepressants. Do not begin or halt any medicine without prior doctor or pharmacist recommendation.

Also inform your doctor of your medical history before taking this medication, especially if you have any history of allergies, prolonged erections from other drugs, cancer, physical penis abnormalities, blood or bleeding disorders, low blood pressure, and heart disease. You should also be aware that this drug offers zero protection against sexually transmitted infections such as Hepatitis B or HIV (AIDS).

Overdosing with alprostadil can lead to having a painful and persistent erection for hours on end. If left untreated, this side effect can cause you to have a permanent inability to have an erection. Seek emergency medical attention once you get a prolonged and agonizing erection after using this drug.

Alprostadil has the following structural formula:

Chemical structure of alprostadil

• Molecular formula of alprostadil is C20H34O5
• Chemical IUPAC Name is 7-[3-hydroxy-2-(3-hydroxyoct-1-enyl)-5-oxo-cyclopentyl]heptanoic acid
• Molecular weight is 354.481 g/mol
Alprostadil available : 500mg tablets

Brand name(s): Befar, Caverject, Edex, Muse, Prink, Prostaglandin E1, Prostin VR

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