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Alteplase

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Alteplase

Alteplase review





Alteplase is a medication used to treat all sorts of blood-clot-related conditions. Alterplase also refers to a naturally occurring enzyme found in humans that causes blood clots to dissolve and dissipate. The drug form of alterplase is a manmade protein manufactured using recombinant DNA technology.

The amount of alterplase given to blood-cot-suffering patients is a lot more than the amount biologically made by the body itself. First approved for heart attacks in 1987, alterplase was eventually approved for stroke treatment in 1996.

Alteplase, also known as Flexyx's Activase, is an injectable medication administered directly into a vein in order to treat people with conditions caused by arterial blood clots, which includes pulmonary thrombosis (blood clots in the lungs), unstable angina (chest pain at rest), strokes, heart attacks, and other less common sicknesses involving blood clots.

The advised daily dose for alterplase is based upon the patient's weight and limited to a maximum amount of 100 milligrams. It is injected intravenously. Depending on the severity of the patient's condition, the drug is either administered once quickly or as a brief infusion for a period of half an hour to an hour.

You can also mix the drug's powder with sterile water for injection at concentrations of 50 milligrams per 50 milliliters to 100 milligrams per 100 milliliters. The vials should be stored at room temperature up to 30C (80F) or inside a freezer at 2-8 C (36-46 F). Once it is mixed with sterile water, the drug must be used without delay. All unused solutions should be discarded immediately.

Bleeding is the most common and serious side effect of alteplase therapy. Most bleeding is fortunately minor, but it is also significant, and fatal bleeding does occur. Other typical side effects include mild fever, dizziness, vomiting, and nausea. If any of these symptoms persist or become worse, promptly seek medical attention.

You should also consult your doctor if you experience chest pain, rapid or abnormal heartbeat, breathing difficulties, skin rash, easy bruising, and easy bleeding. You should also notify as soon as possible any signs or symptoms of bleeding to your designated healthcare specialist. Even if you experience other symptoms not listed above, you should still contact your pharmacist or doctor and tell them your complaints.

Before undergoing alterplase treatment, inform your doctor of your medical history, especially if you have the following concerns: allergies of any kind, endocarditis, liver disease, recent injury or surgery, high blood pressure, and other bleeding disorders. You should also practice extra caution in order to avoid trauma or injury while using this medication because of the added risk of bleeding.

If you're a pregnant mother-to-be, his drug should only be used when clearly needed. Consult your doctor in regards to the pros and cons of using this medicine while pregnant. You should also discuss with him whether or not you should breastfeed while under alterplase therapy.

You should also remember that alteplase's ability to break down clots can interfere with your body's ability to stop bleeding. As such, any medication that also interferes with blood clotting or the clot-inducing abilities of platelets can increase your chances of actually bleeding to death.

Indeed, it would be best for you to avoid NSAIDs (nonsteroidal anti-inflammatory drugs) like Relafen (nabumetone), Naprosyn (naproxen), and Motrin (ibuprofen) or medications like Coumadin (warfarin) and aspirin. Then again, specific platelet inhibitors like Plavix (clopidogrel) don't appear to interact badly with alteplase to increase your risk of bleeding. As always, consult your doctor or pharmacist for more details.

• Molecular formula of alteplase is C2561H3919N747O781S40
• Molecular weight is 58951.2 g/mol

Brand name(s): Activase, Reteplase

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