Altretaminum review

Altretaminum, also known by the trade name Hexalen, is an antineoplastic agent that is used to treat refractory ovarian cancer. However, it isn't regarded as a first-line treatment for the disease and is instead used as salvage therapy. It has the major benefit of not being as toxic as other medicaments currently being used to treat refractory ovarian cancer. Hydroxymethylmelamines are the active metabolite for this medicament. Altretaminum was approved by the Food and Drug Administration (FDA) in 1990.

Altretaminum is recommended for patients who have refractory ovarian cancer that has persisted or recurred after treatment with other anti-cancer medicaments. It has also been used to treat lung cancer even though that isn't an approved use of the medicine.

At present, this agent's precise mechanism of action and the reason behind its anti-cancer effect is unknown, but MeSH (Medical Subject Headings) has nevertheless classified it as an alkylating antineoplastic agent.

A patient's height and weight are major factors in determining the proper dose of Altretaminum. This medicament should be taken orally as instructed by your doctor. It's usually taken at bedtime and after meals. You should not increase your dose, take it more frequently than necessary, or halt treatment without prior medical consultation.

This medicine may be administered either for two or three consecutive weeks as part of one or more twenty-eight day cycles. The recommended daily dose of Altretaminum is usually split into four oral doses after breakfast, lunch, dinner, and before bedtime.

The most common side effect of Altretaminum is emesis and gradual-onset nausea. Central nervous system symptoms (vertigo, dizziness, ataxia, disorders of consciousness, mood disorders) and peripheral neuropathy (tingling and numbness because of the abnormal function of the sensory nerves of the legs and arms) have also been reported. Luckily, these symptoms appear to be reversible.

You should note that Altretaminum therapy may cause platelet and white blood cell counts to decrease, which increase the risk of bleeding and infection respectively. Seek immediate medical attention if you develop symptoms of blood disorders or nervous system problems such as the tingling of your hands or feet, mood changes, loss of coordination, easy bruising or bleeding, or persistent pyrexia or acute pharyngitis.

Before taking this medicament, be sure to inform your doctor if you have any allergies (especially medical allergies), blood disorders, nervous system disease, and seizure disorders. If after taking this medicament you suffer from dizziness, practice caution when operating heavy machinery or driving. You should also be careful when climbing stairs or rising from a seated position.

Blood tests must first be conducted on a patient before starting treatment (and once a month during treatment) because Altretaminum has been known to cause blood problems like thrombocytopenia and bone marrow suppression. You should also be aware that this medicament has been known to cause nervous system problems, so nervous system tests must be conducted too.

It is discouraged for expecting mothers to use Altretaminum. Ask your doctor for more information in regards to pregnancy and Altretaminum use. It is also currently unknown whether or not this medicament passes into breast milk, so it would be best for nursing mothers to stop breastfeeding while under Altretaminum therapy. Consult your doctor for more details.

Altretaminum may cause severe orthostatic abnormally low blood pressure (a sudden decrease in blood pressure) upon standing when given to patients undergoing antidepressant therapy of the Monoamine oxidase inhibitor class. Moreover, Tagamet (cimetidine) may hamper the purging of Altretaminum from your body, which may increase your risk side effects. Conversely, Vitamin B6 (pyridoxine) can reduce the risk of neurotoxicity, but can also reverse the beneficial effects of Altretaminum in treating ovarian cancer.

Altretaminum has the following structural formula:

Chemical structure of altretaminum

• Molecular formula of altretaminum is C9H18N6
• Chemical IUPAC Name is N2,N2,N4,N4,N6,N6-hexamethyl-1,3,5-triazine-2,4,6-triamine
• Molecular weight is 210.28 g/mol
Altretaminum available : 50mg capsules

Generic name: Altretamine

Brand name(s): Hemel, Hexalen, Hexastat

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